ACSS2

ACSS2, or Acetyl-CoA Synthase 2, is also known as ACS, ACSA, ACAS2, and ACECS. ACSS2 is a cytoplasmic enzyme that catalyzes the activation of acetic acid for lipid synthesis and energy production. By converting acetic acid to acetyl-CoA under ATP-dependent conditions, this process is crucial for cellular metabolic activities.
ACSS2 plays a significant role in cell proliferation and gene expression regulation, particularly in the growth and metabolism of tumor cells. Abnormal activity and expression of ACSS2 are closely associated with tumor proliferation, invasion, metastasis, anti-apoptosis, and drug resistance.