ACTL6B Antibody

Code CSB-PA001237ESR2HU
Size US$166
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  • Western blot
    All lanes: Actin-like protein 6B antibody at 3μg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: U251 whole cell lysate
    Lane 3: HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 47 kDa
    Observed band size: 47 kDa

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA001237ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA001237ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ACTL6B Polyclonal antibody
Uniprot No.
Target Names
ACTL6B
Alternative Names
53 kDa BRG1 associated factor B antibody; 53 kDa BRG1-associated factor B antibody; ACL 6B antibody; ACL6B antibody; ACL6B_HUMAN antibody; Actin like 6 antibody; Actin like protein 6B antibody; Actin like protein6B antibody; Actin related protein antibody; Actin related protein Baf53b antibody; actin-like 6B antibody; Actin-like protein 6B antibody; Actin-related protein Baf53b antibody; Actl 6 antibody; ACTL 6B antibody; Actl6 antibody; ACTL6 B antibody; Actl6b antibody; Arp Na antibody; ArpN a antibody; ArpN alpha antibody; ArpNa antibody; ArpNalpha antibody; Baf 53b antibody; BAF53B antibody; BRG1-associated factor 53B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Actin-like protein 6B protein (1-280AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:1000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development.
Gene References into Functions
  1. Missense Mutation in ACTL6B gene is associated with Neurodevelopmental Disorders. PMID: 28867141
  2. we identified BAF53b as a neuron-specific subunit of the chromatin remodeling BAF complexes. PMID: 26077106
  3. Data suggest that SWI/SNF complexes containing ArpN alpha might regulate certain genes involved in brain development and/or its function differently from SWI/SNF complexes containing ArpN beta/BAF53. PMID: 12565893
Subcellular Location
Nucleus.
Protein Families
Actin family
Database Links

HGNC: 160

OMIM: 612458

KEGG: hsa:51412

STRING: 9606.ENSP00000160382

UniGene: Hs.259831

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