ADAMTS17 Antibody

Datasheet

Code	CSB-PA485300
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA485300(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA485300(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: CSB-PA485300(ADAMTS17 Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 hour
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Product Details
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Target Background

Product Details

Uniprot No.

Q8TE56

Target Names

ADAMTS17

Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 17 antibody; A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif; 17 antibody; ADAM metallopeptidase with thrombospondin type 1 motif; 17 antibody; ADAM-TS 17 antibody; ADAM-TS17 antibody; ADAMTS 17 antibody; ADAMTS-17 antibody; ADAMTS17 antibody; ATS17_HUMAN antibody; EC 3.4.24. antibody; FLJ16363 antibody; FLJ32769 antibody; OTTHUMP00000194818 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human ADAMTS17

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Gene References into Functions

Secretion of ADAMTS17 requires O-fucosylation. ADAMTS17 binds fibrillin-2 but not fibrillin-1 and does not cleave either. ADAMTS17 regulates fibrillin isoform composition of microfibrils in the eye. PMID: 28176809
higher Adamts17 expression is found in several human cancer cell subtypes, especially in breast ductal carcinoma and there is an inverse correlation between higher Adamts17 expression and patients' survival. PMID: 24906090
The mutation in the Weill-Marchesani syndrome (WMS)- gene ADAMTS17 also causes WMS in an Indian family. PMID: 24940034
A mutation in WMS-like gene ADAMTS17 also causes WMS. PMID: 24940034
Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition. PMID: 23661674
Recessive ADAMTS17 mutations are a recurrent cause of isolated spherophakia with short stature. PMID: 22486325
ADAMTS17 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
Homozygous mutation in ADAMTS17 causes lenticular myopia, ectopia lentis, glaucoma, spheropakia, and short stature. PMID: 19836009

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Involvement in disease

Weill-Marchesani-like syndrome (WMSL)

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Tissue Specificity

Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle

Database Links

HGNC: 17109

OMIM: 607511

KEGG: hsa:170691

STRING: 9606.ENSP00000268070

UniGene: Hs.513200

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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