ADD3 Antibody

1. ADD3 and ADD3-AS1 variants increased susceptibility to BA, suggesting that these genes may play an additive role in the pathogenesis of the disease. PMID: 29508064
2. Data indicate lysine acetyltransferase 2B (KAT2B) as a susceptibility gene for kidney and heart disease in adducin 3 (gamma) protein (ADD3)-associated disorders. PMID: 29768408
3. MiR-145-5p was confirmed to target ADD3 by luciferase reporter assay. The downregulation of miR-145 may contribute to liver fibrosis in Biliary atresia by upregulating the expression of ADD3. PMID: 28902846
4. ADD3 gene deletion is associated with acute lymphoblastic leukemia. PMID: 28033648
5. ADD3 gene plays an important role in biliary atresia pathogenesis. PMID: 25285724
6. Common genetic variants in 10q24.2 can alter biliary atresia risk by regulating ADD3 expression levels in the liver, and may exert an effect on disease epidemiology and on the general population. PMID: 23872602
7. High expression of ADD3 is associated with glioma. PMID: 23814265
8. ADD3 gene may be functionally relevant for the development of biliary atresia PMID: 24104524
9. Homozygous p.G367D mutation in ADD3 causes spastic diplegic/quadriplegic cerebral palsy and intellectual disability. PMID: 23836506
10. gamma-adducin may influence blood pressure homeostasis by modulating renal NaCl transport. PMID: 21164023
11. The early expression of ADD3 suggests that it may have a role in erythroblasts but is replaced by ADD2 in later stages of erythropoiesis. PMID: 15963851
12. Left ventricular diastolic relaxation is modulated by genetic variation in ADD3. PMID: 18475162
13. In ADD1 GlyGly homozygotes, the properties of the brachial artery are related to the ADD3 (A386G) polymorphism, but the underlying mechanism needs further clarification. PMID: 18787518

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HGNC: 245

OMIM: 601568

KEGG: hsa:120

STRING: 9606.ENSP00000348381

UniGene: Hs.501012