ADGRA2 Antibody

Code CSB-PA857001LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: A549 whole cell lysate, Rat heart tissue
    All lanes: ADGRA2 antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 143, 120, 20 kDa
    Observed band size: 143, 120 kDa

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA857001LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA857001LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ADGRA2 Polyclonal antibody
Uniprot No.
Target Names
ADGRA2
Alternative Names
DKFZp434C211 antibody; DKFZp434J0911 antibody; FLJ14390 antibody; G protein coupled receptor 124 antibody; G-protein coupled receptor 124 antibody; GP124_HUMAN antibody; GPR 124 antibody; Gpr124 antibody; KIAA1531 antibody; TEM 5 antibody; TEM5 antibody; Tumor endothelial marker 5 antibody; Tumor endothelial marker 5 precursor antibody
Raised in
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant Human Adhesion G protein-coupled receptor A2 protein (1069-1338AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ADGRA2 Antibody (Product code: CSB-PA857001LA01HU) is Non-conjugated. For ADGRA2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA857001LB01HU ADGRA2 Antibody, HRP conjugated ELISA
FITC CSB-PA857001LC01HU ADGRA2 Antibody, FITC conjugated
Biotin CSB-PA857001LD01HU ADGRA2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly. Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate.
Gene References into Functions
  1. Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1-Dock180 and intersectin 1/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 = ELMO domain-containing protein 1; Dock180 = dedicator of cytokinesis protein 1 180 kDa) PMID: 28600358
  2. Observed an inverse correlation between the expression of miR-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR-138-5p on the sensitivity to gefitinib. PMID: 24582749
  3. Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase. PMID: 22013897
  4. TEM5 expression during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of proliferation in endothelial cells. PMID: 19853600
  5. Proteolytically processed soluble tumor endothelial marker TEM5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans PMID: 16982628

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell projection, filopodium.
Protein Families
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Tissue Specificity
Expressed in endothelial cells (at protein level). Abundantly expressed in heart, placenta, ovary, small intestine, and colon.
Database Links

HGNC: 17849

OMIM: 606823

KEGG: hsa:25960

STRING: 9606.ENSP00000406367

UniGene: Hs.274136

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