ADH7 Antibody

Datasheet

Code	CSB-PA001362LA01HU
Size	US$166
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Image	Western blot All lanes: ADH7 antibody at 2µg/ml + Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 42, 43 kDa Observed band size: 42 kDa Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA001362LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA001362LA01HU at dilution of 1:100 Immunofluorescence staining of HepG2 cells with CSB-PA001362LA01HU at 1:133,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ADH7 Polyclonal antibody

Uniprot No.

P40394

Target Names

ADH7

Alternative Names

ADH7 antibody; All-trans-retinol dehydrogenase [NAD(+)] ADH7 antibody; EC 1.1.1.105 antibody; Alcohol dehydrogenase class 4 mu/sigma chain antibody; EC 1.1.1.1 antibody; Alcohol dehydrogenase class IV mu/sigma chain antibody; Gastric alcohol dehydrogenase antibody; Omega-hydroxydecanoate dehydrogenase ADH7 antibody; EC 1.1.1.66 antibody; Retinol dehydrogenase antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Alcohol dehydrogenase class 4 mu/sigma chain protein (1-386AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ADH7 Antibody (Product code: CSB-PA001362LA01HU) is Non-conjugated. For ADH7 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA001362LB01HU	ADH7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001362LC01HU	ADH7 Antibody, FITC conjugated
Biotin	CSB-PA001362LD01HU	ADH7 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The ADH7 antibody is a polyclonal antibody that is generated in rabbits by immunizing with recombinant human Alcohol dehydrogenase class 4 mu/sigma chain protein (1-386aa). The primary function of the ADH7 polyclonal antibody is to recognize and bind to the ADH7 protein in samples from both human and mouse species.

The ADH7 antibody is protein G purified, with a purity greater than 95%, which ensures its high quality and reliability. This antibody has been tested for use in a range of applications, including ELISA, WB, IHC, and IF. Its availability in different applications allows for the investigation of the expression and localization of ADH7 in different tissues and cells in human and mouse samples.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation.

Gene References into Functions

These results suggest that variants near ADH7 may play a role in protection from alcohol dependence in this Mexican American cohort. PMID: 25527893
Transcriptional regulatory elements of ADH7 were identified that effect gene expression. PMID: 24512552
common ADH1-7 variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans. PMID: 23468174
The rs1573496 (ADH7) polymorphism was not associated with colorectal cancer risk overall in Western-European populations. However, the relationship between alcohol and colorectal cancer risk might be modulated by the rs1573496 (ADH7) polymorphism. PMID: 23149980
The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations. PMID: 20336794
An association between age at onset of regular alcohol use and a SNP just upstream of ADH7 (rs2654849, p = .003) was observed. PMID: 20158305
ADH7 gene polymorphisms are associated with upper aerodigestive tract cancers. PMID: 19861527
the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared. PMID: 17918242
A recombinational hotspot within intron 7 of the ADH7 gene were seen using 25 SNPs; haplotypes associated with inter-individual variation in the early stages of alcohol metabolism were identified. PMID: 17921519
Changes in the activity of class IV ADH in the sera of patients with gastric cancer seems to be caused by release of the isoenzyme from cancer cells. PMID: 18231859
Single Nucleotide Polymorphism in ADH7 gene is associated with upper aerodigestive cancer. PMID: 18500343

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Subcellular Location

Cytoplasm.

Protein Families

Zinc-containing alcohol dehydrogenase family, Class-IV subfamily

Tissue Specificity

Preferentially expressed in stomach.

Database Links

HGNC: 256

OMIM: 600086

KEGG: hsa:131

STRING: 9606.ENSP00000420269

UniGene: Hs.389

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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