Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

ADH7

Uniprot No.

P40394

Research Area

Metabolism

Alternative Names

ADH7; All-trans-retinol dehydrogenase [NAD(+)] ADH7; EC 1.1.1.105; Alcohol dehydrogenase class 4 mu/sigma chain; EC 1.1.1.1; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Omega-hydroxydecanoate dehydrogenase ADH7; EC 1.1.1.66; Retinol dehydrogenase

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

1-386aa

Target Protein Sequence

MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.

Mol. Weight

45.5kDa

Protein Length

Full Length

Tag Info

N-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

Tris-based buffer,50% glycerol

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Target Background

Function

Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation.

Gene References into Functions

These results suggest that variants near ADH7 may play a role in protection from alcohol dependence in this Mexican American cohort. PMID: 25527893
Transcriptional regulatory elements of ADH7 were identified that effect gene expression. PMID: 24512552
common ADH1-7 variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans. PMID: 23468174
The rs1573496 (ADH7) polymorphism was not associated with colorectal cancer risk overall in Western-European populations. However, the relationship between alcohol and colorectal cancer risk might be modulated by the rs1573496 (ADH7) polymorphism. PMID: 23149980
The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations. PMID: 20336794
An association between age at onset of regular alcohol use and a SNP just upstream of ADH7 (rs2654849, p = .003) was observed. PMID: 20158305
ADH7 gene polymorphisms are associated with upper aerodigestive tract cancers. PMID: 19861527
the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared. PMID: 17918242
A recombinational hotspot within intron 7 of the ADH7 gene were seen using 25 SNPs; haplotypes associated with inter-individual variation in the early stages of alcohol metabolism were identified. PMID: 17921519
Changes in the activity of class IV ADH in the sera of patients with gastric cancer seems to be caused by release of the isoenzyme from cancer cells. PMID: 18231859
Single Nucleotide Polymorphism in ADH7 gene is associated with upper aerodigestive cancer. PMID: 18500343

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Subcellular Location

Cytoplasm.

Protein Families

Zinc-containing alcohol dehydrogenase family, Class-IV subfamily

Tissue Specificity

Preferentially expressed in stomach.

Database Links

HGNC: 256

OMIM: 600086

KEGG: hsa:131

STRING: 9606.ENSP00000420269

UniGene: Hs.389

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Code	CSB-EP001362HU
MSDS	MSDS
Size	$224
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human All-trans-retinol dehydrogenase [NAD (+)] ADH7 (ADH7)

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