ADI1 Antibody

Datasheet

Code	CSB-PA001364GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9BV57

Target Names

ADI1

Alternative Names

1 2 dihydroxy 3 keto 5 methylthiopentene dioxygenase antibody; 1 antibody; 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase antibody; Aci reductone dioxygenase antibody; Acireductone dioxygenase (Fe(2+) requiring) antibody; Acireductone dioxygenase (Ni(2+) requiring) antibody; Acireductone dioxygenase (Ni(2+)-requiring) antibody; Acireductone dioxygenase 1 antibody; ADI 1 antibody; Adi1 antibody; ADI1 antibody antibody; APL1 antibody; ARD antibody; EC 1.13. antibody; Fe ARD antibody; FLJ10913 antibody; HMFT1638 antibody; Membrane type 1 matrix metalloproteinase cytoplasmic tail binding protein 1 antibody; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1 antibody; MT1 MMP cytoplasmic tail binding protein 1 antibody; MTCBP 1 antibody; MTCBP-1 antibody; MTCBP1 antibody; MTND_HUMAN antibody; Ni-ARD antibody; SIPL antibody; Submergence induced protein 2 antibody; Submergence induced protein 2 homolog antibody; Submergence induced protein like factor antibody; Submergence-induced protein 2 homolog antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human ADI1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.

Gene References into Functions

High ADI1 expression is associated with malignant glioma. PMID: 30066900
The thermal stability of the HsARD isozymes is a function of the metal ion identity, with Ni2+-bound HsARD being the most stable followed by Co2+ and Fe2+, and Mn2+-bound HsARD being the least stable. PMID: 28062648
In summary, clinical and cell-based experiments suggested that physical interaction between MT1-MMP and ADI1 led to suppression of hepatitis C virus infection. This inhibitory effect could be reversed by ADI1 overexpression. PMID: 26537061
Data elucidate a new role for MTCBP-1 regulating the intracellular function of MT1-MMP-mediated autophagy. Their inverse expression correlation with brain tumor grades could also contribute to the decreased autophagic index observed in high-grade tumors. PMID: 25640948
MTCBP-1 is a new member of the Cupin superfamily with a role as an invasion suppressor down-regulated in tumors PMID: 14718544
nucleo-cytoplasmic transport of hADI1 is regulated by a non-canonical nuclear export signal (NES) located in the N-terminal region of hADI1. PMID: 17212658
ADI1 may check prostate cancer progression through apoptosis by an activity that does not require metal binding. PMID: 17786183
293-ADI1-CD81 cells are permissive for serum-derived HCV infection. PMID: 19626614

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Subcellular Location

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.

Protein Families

Acireductone dioxygenase (ARD) family

Tissue Specificity

Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.

Database Links

HGNC: 30576

OMIM: 613400

KEGG: hsa:55256

STRING: 9606.ENSP00000333666

UniGene: Hs.502773

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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