AGFG1 Antibody

Code CSB-PA030856
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA030856(AGFG1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA030856(AGFG1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A172 cells, Hela cells, 293T cells, K562 cells, human testis tissue, Primary antibody: CSB-PA030856(AGFG1 Antibody) at dilution 1/533, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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Product Details

Uniprot No.
Target Names
AGFG1
Alternative Names
AGFG1 antibody; AGFG1_HUMAN antibody; Arf-GAP domain and FG repeats-containing protein 1 antibody; ArfGAP with FG repeats 1 antibody; AU045498 antibody; C130049H11Rik antibody; C85612 antibody; D730048C23Rik antibody; DKFZp686I15205 antibody; HIV 1 Rev binding protein antibody; HIV-1 Rev-binding protein antibody; HRB antibody; MGC116375 antibody; MGC116938 antibody; MGC116940 antibody; Nucleoporin like protein RIP antibody; Nucleoporin-like protein RIP antibody; RAB antibody; Rev interacting protein antibody; Rev-interacting protein antibody; Rev/Rex activation domain-binding protein antibody; RIP antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein of Human AGFG1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
Gene References into Functions
  1. Necroptotic RIP1 phosphorylation and ubiquitination seem to be tightly coordinated: inhibition or absence of RIP1 kinase activity blocks necroptotic RIP1 ubiquitination, whereas mutation of RIP1 necroptosis-associated ubiquitination site (K115R) dampens RIP1 kinase activity during necroptotic signaling. PMID: 27518435
  2. HRB knock-down affected CD4 downregulation induced by Nef but not by HIV-1 Vpu. PMID: 26701340
  3. Selenite caused CYLD upregulation via LEF1 and cIAP downregulation, both of which contribute to the degradation of ubiquitin chains on RIP1 and subsequent caspase-8 activation and colorectal tumor cell apoptosis. PMID: 24577083
  4. The top primary GWAS association of Airway hyperresponsiveness was in rs6731443 (P-value 2.5E-06) located within the AGFG1 genes. PMID: 23984888
  5. Association ofalpha-synuclein with Rab attachment receptor protein and soluble sensitive factor attachment receptors (SNAREs) highlights a key role for membrane transport defects in alpha-synuclein-mediated pathology. PMID: 21439320
  6. The authors show that cells lacking functional HRB have significantly reduced production of influenza virus progeny and that this defect results from impaired viral ribonucleoprotein (vRNP) delivery to the plasma membrane. PMID: 21752912
  7. hRIP is an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export. PMID: 14701878
  8. Study demonstrates that the clathrin-mediated endocytosis of the SNARE VAMP7 is directly mediated by Hrb, a clathrin adaptor and ArfGAP. PMID: 18775314
  9. HRB is involved in clathrin-dependent endocytosis and recruits TI-VAMP in this process PMID: 18819912

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Subcellular Location
Nucleus. Cytoplasmic vesicle.
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 5175

OMIM: 600862

KEGG: hsa:3267

STRING: 9606.ENSP00000387282

UniGene: Hs.352962

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