AHSA1 Antibody

Code CSB-PA05455A0Rb
Size US$166
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  • Western blot
    All lanes: AHSA1 antibody at 2µg/ml
    Lane 1: EC109 whole cell lysate
    Lane 2: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/15000 dilution
    Predicted band size: 39, 33 kDa
    Observed band size: 45 kDa

  • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA05455A0Rb at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AHSA1 Polyclonal antibody
Uniprot No.
Target Names
AHSA1
Alternative Names
Activator of 90 kDa heat shock protein ATPase homolog 1 antibody; Activator of heat shock 90kDa protein ATPase homolog 1 antibody; AHA 1 antibody; AHA1 antibody; AHSA 1 antibody; Ahsa1 antibody; AHSA1_HUMAN antibody; C14orf3 antibody; HSPC322 antibody; p38 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Activator of 90 kDa heat shock protein ATPase homolog 1 protein (1-338AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The AHSA1 Antibody (Product code: CSB-PA05455A0Rb) is Non-conjugated. For AHSA1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA05455B0Rb AHSA1 Antibody, HRP conjugated ELISA
FITC CSB-PA05455C0Rb AHSA1 Antibody, FITC conjugated
Biotin CSB-PA05455D0Rb AHSA1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins.
Gene References into Functions
  1. Aha1 colocalized with tau pathology in brain tissue, and this association positively correlated with Alzheimer disease progression. PMID: 28827321
  2. These results suggest that differences in the middle domain of Hsp90alpha and Hsp90beta may be responsible for the isoform-specific interactions with selected proteins. PMID: 25486457
  3. Aha1 may promote disposal of folding defective proteins by the cellular protein quality control. PMID: 25378400
  4. a monoallelic mutation of p53 was sufficient to activate the Aha1/Hsp90 ATPase axis leading to stimulation of Wnt signaling and increased expression of Wnt target genes. PMID: 24451373
  5. Modulation of Hsp90 activity by AHA1 regulates VEGF signaling to eNOS and angiogenesis. PMID: 22859491
  6. The interaction of Aha1 with Hsp90 and its co-chaperones in rabbit reticulocyte lysate (RRL) and in HeLa cell extracts, was characterized. PMID: 22504172
  7. Hsp90 phosphorylation on tyrosine313 promotes recruitment of AHA1, which stimulates Hsp90 ATPase activity, furthering the chaperoning process. PMID: 22727666
  8. Data propose a model for Aha1 in the Hsp90 ATPase cycle where Aha1 regulates dwell time of Hsp90, and suggest Aha1 activity integrates chaperone function with client folding energetics by modulating ATPase sensitive dimer structural transitions. PMID: 20089831
  9. stimulates the inherent ATPase activity of Hsp90 PMID: 12504007
  10. Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR protein folding in the endoplasmic reticulum PMID: 17110338

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Subcellular Location
Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum.
Protein Families
AHA1 family
Tissue Specificity
Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
Database Links

HGNC: 1189

OMIM: 608466

KEGG: hsa:10598

STRING: 9606.ENSP00000216479

UniGene: Hs.204041

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