AKAP1 Antibody

Code CSB-PA001518GA01HU
Size US$685
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Product Details

Uniprot No. Q92667
Target Names AKAP1
Alternative Names A kinase anchor protein antibody; A-kinase anchor protein 1 antibody; A-kinase anchor protein 149 kDa antibody; AKAP 149 antibody; AKAP antibody; Akap1 antibody; AKAP1_HUMAN antibody; D-AKAP-1 antibody; DAKAP1 antibody; Dual specificity A-kinase-anchoring protein 1 antibody; mitochondrial antibody; PRKA1 antibody; Protein kinase A-anchoring protein 1 antibody; Protein kinase A1 antibody; S-AKAP84 antibody; SAKAP84 antibody; Spermatid A-kinase anchor protein 84 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Human AKAP1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC,IF
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
Gene References into Functions
  1. AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. PMID: 28569781
  2. Furthermore, we discuss the role of hypoxia in prompting cellular stress and damage, which has been demonstrated to mediate the proteosomal degradation of AKAP121, leading to an increase in reactive oxgyen species production, mitochondrial dysfunction, and ultimately cell death. [review] PMID: 26825124
  3. Functional characterization revealed an undescribed role for AMPK-dependent phosphorylation of AKAP1 in mitochondrial respiration. PMID: 26437602
  4. AKAP 149-PKA-PDE4A complex localization is related with YTX effect in K-562 cell line PMID: 24813785
  5. In the case of the beta2AR, this process is facilitated by the presence of A-Kinase Anchoring Proteins (AKAPs) that serve as scaffolding proteins for the L-type calcium channel and the beta2AR complex. PMID: 23557075
  6. AKAP1 anchors Star mRNA at the mitochondria, thus stabilizing the translational complex at this organelle, a situation that might affect STAR production and steroidogenesis. PMID: 23077346
  7. In tumoural lymphocytes, yessotoxin decreases AKAP149 cytosolic expression and increases cAMP levels which leads to cell death. PMID: 22807343
  8. Shp2 is a component of the AKAP-Lbc complex and is inhibited by protein kinase A under pathological hypertrophic conditions in the heart. PMID: 23045525
  9. AMY-1 interacts with this and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. PMID: 12414807
  10. RIalpha and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bind to the R-binding domain of AKAP149/D-AKAP1 PMID: 12634056
  11. AKAP149-regulated PP1 activity at the NE during G1 is required to maintain nuclear integrity and cell survival. PMID: 12697839
  12. DAKAP1alpha overexpression induced regulatory (R) or catalytic (C) subunits of PKA to outer mitochondrial colocalization and showed similar regulation PMID: 17884635
  13. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701
  14. Results suggest that the interaction between reverse transcriptase and AKAP149 in infected cells may play an important role in HIV-1 reverse transcription. PMID: 18786546
  15. Protein phosphatase 1 binding occurs through a conserved RVXF motif found in the KH domain of AKAP149. PMID: 19074462

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Subcellular Location Mitochondrion outer membrane
Tissue Specificity Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250).
Database Links

HGNC: 367

OMIM: 602449

KEGG: hsa:8165

STRING: 9606.ENSP00000337736

UniGene: Hs.463506

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