AKIP1 Antibody

Code CSB-PA868282LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA868282LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AKIP1 Polyclonal antibody
Uniprot No.
Target Names
AKIP1
Alternative Names
AKIP1 antibody; BCA3 antibody; C11orf17A-kinase-interacting protein 1 antibody; Breast cancer-associated gene 3 protein antibody; PKA-interacting protein antibody; Proline-rich protein BCA3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human A-kinase-interacting protein 1 protein (57-167AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The AKIP1 Antibody (Product code: CSB-PA868282LA01HU) is Non-conjugated. For AKIP1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA868282LB01HU AKIP1 Antibody, HRP conjugated ELISA
FITC CSB-PA868282LC01HU AKIP1 Antibody, FITC conjugated
Biotin CSB-PA868282LD01HU AKIP1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
Gene References into Functions
  1. These results show that AKIP1 is crucial in cervical cancer angiogenesis and growth by elevating the levels of the NF-kappaB-dependent chemokines CXCL1, CXCL2, and CXCL8. PMID: 29520695
  2. Breast carcinoma-associated protein (BCA3) is packaged into Human immunodeficiency virus 1 (HIV-1) particles, and the BCA3 C-terminus is responsible for this incorporation. BCA3 incorporation into HIV-1 particles is mediated by its ability to interact with the catalytic subunit of protein kinase A. There is no effect of incorporated BCA3 on HIV-1 infectivity. PMID: 29677171
  3. The pleiotropic effects of BCA3 in HCC progression. PMID: 29133128
  4. The absence of exon 3 and exon 5 influenced the subcellular localization of BCA3 and nuclear factor kappa B (NF-kB)-dependent gene expression. PMID: 25526186
  5. Data indicate an important role for A-kinase-interacting protein 1 (AKIP1) in esophageal squamous cell carcinoma (ESCC) angiogenesis and lymphangiogenesis. PMID: 24413079
  6. Expression of BCA3 did not affect Mason-Pfizer money virus (MPMV) particle release and proteolytic processing; however, it slightly increased MPMV infectivity. PMID: 24659101
  7. Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart. PMID: 23319652
  8. action of PKA signaling on the NF-kappaB activation cascade PMID: 20562110
  9. characterization of the BCA3 gene; BCA3 is expressed in breast tumor cells in vivo, and not in surrounding stromal tissue PMID: 12527432
  10. AKIP1 describes a PKA-interacting protein that can contribute to localization by a mechanism that is distinct from A-kinase anchoring proteins that interact with the regulatory subunits. PMID: 15630084
  11. AKIP1 colocalized with p65 within the cells and appeared to retain p65 in nucleus. PMID: 18178962

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Subcellular Location
Nucleus. Note=Locates to punctate spots.
Tissue Specificity
Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.
Database Links

HGNC: 1170

OMIM: 609191

KEGG: hsa:56672

STRING: 9606.ENSP00000310459

UniGene: Hs.131180

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