AKIP1 Antibody

Code CSB-PA956447
Size US$297
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  • Western blot analysis of extracts from Jurkat cells, using BCA3 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human heart tissue using BCA3 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AKIP1 Polyclonal antibody
Uniprot No.
Target Names
AKIP1
Alternative Names
AKIP1 antibody; BCA3 antibody; C11orf17A-kinase-interacting protein 1 antibody; Breast cancer-associated gene 3 protein antibody; PKA-interacting protein antibody; Proline-rich protein BCA3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human BCA3.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
Gene References into Functions
  1. These results show that AKIP1 is crucial in cervical cancer angiogenesis and growth by elevating the levels of the NF-kappaB-dependent chemokines CXCL1, CXCL2, and CXCL8. PMID: 29520695
  2. Breast carcinoma-associated protein (BCA3) is packaged into Human immunodeficiency virus 1 (HIV-1) particles, and the BCA3 C-terminus is responsible for this incorporation. BCA3 incorporation into HIV-1 particles is mediated by its ability to interact with the catalytic subunit of protein kinase A. There is no effect of incorporated BCA3 on HIV-1 infectivity. PMID: 29677171
  3. The pleiotropic effects of BCA3 in HCC progression. PMID: 29133128
  4. The absence of exon 3 and exon 5 influenced the subcellular localization of BCA3 and nuclear factor kappa B (NF-kB)-dependent gene expression. PMID: 25526186
  5. Data indicate an important role for A-kinase-interacting protein 1 (AKIP1) in esophageal squamous cell carcinoma (ESCC) angiogenesis and lymphangiogenesis. PMID: 24413079
  6. Expression of BCA3 did not affect Mason-Pfizer money virus (MPMV) particle release and proteolytic processing; however, it slightly increased MPMV infectivity. PMID: 24659101
  7. Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart. PMID: 23319652
  8. action of PKA signaling on the NF-kappaB activation cascade PMID: 20562110
  9. characterization of the BCA3 gene; BCA3 is expressed in breast tumor cells in vivo, and not in surrounding stromal tissue PMID: 12527432
  10. AKIP1 describes a PKA-interacting protein that can contribute to localization by a mechanism that is distinct from A-kinase anchoring proteins that interact with the regulatory subunits. PMID: 15630084
  11. AKIP1 colocalized with p65 within the cells and appeared to retain p65 in nucleus. PMID: 18178962

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Subcellular Location
Nucleus. Note=Locates to punctate spots.
Tissue Specificity
Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.
Database Links

HGNC: 1170

OMIM: 609191

KEGG: hsa:56672

STRING: 9606.ENSP00000310459

UniGene: Hs.131180

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