AKR1B1 Antibody

1. Here, we show that treatment of colorectal cancer (CRC) cells with fidarestat increases the efficacy of doxorubicin (DOX)-induced death in HT-29 and SW480 cells and in nude mice xenografts. Aldose reductase inhibition also results in higher intracellular accumulation of DOX and decreases the expression of drug transporter proteins MDR1, MRP1, and ABCG2. PMID: 28600556
2. AKR1B1 rs759853 polymorphism had no association with diabetic retinopathy (DR) risk under all genetic models. However, after subgroup analysis by diabetes mellitus; type, the rs759853 polymorphism was a protective factor against the DR onset in patients with type 1 diabetes mellitus; Subgroup analysis by genotyping method suggested that rs759853 was significantly correlated with decreased risk of DR under dominate model PMID: 30201105
3. A combined gene expression signature of AKR1B10 (low) and AKR1B1 (high) showed a better prognostic stratification of CRC patients independent of confounding factors. PMID: 28929377
4. Data show that cells with higher levels of aldo-keto reductases AKR1B1 and/or AKR1B10 (AKR1Bs) were more sensitive to 2-deoxyglucose (2DG). PMID: 29617059
5. genetic association studies in population in north India: Data suggest that an SNP in promoter region of aldose reductase (C-106T) is associated with peripheral neuropathy in patients with type 2 diabetes mellitus in the population studied. PMID: 28495421
6. Under hyperglycemic conditions, aldose reductase (AR)-mediated sorbitol formation and associated rise in cell volume, which subsequently results in platelet hyperactivation, occur. PMID: 28820747
7. In the Eastern Asians with type 2 diabetes mellitus, the AR gene C-106T gene polymorphism is correlated with an increased risk of diabetic nephropathy; the Eastern Asians with the T allele of AR gene C-106T gene polymorphism might be susceptible to DN PMID: 28651212
8. An meta-analysis showed that aldose reductase C-106T variants appear to influence the risk for diabetic retinopathy in Chinese Han persons (meta-analysis). PMID: 26580232
9. AKR1B1 as a key modulator of tumor aggressiveness and suggests that pharmacologic inhibition of AKR1B1 has the potential to become a valuable therapeutic strategy for Basal-like breast cancer (BLBC). PMID: 28270406
10. inhibiting AR or degrading H2O2 could protect endothelial function and maintain the antioxidant activities of uric acid. PMID: 28057038
11. Result indicate that the differential scanning fluorimetry (DSF) method is useful for enzyme inhibitor drug screening for the AKR superfamily, including AKR1B10 and a structurally similar isoform AKR1B1. PMID: 28003428
12. The hyperosmotic AR gene expression was dependent on activation of metalloproteinases, autocrine/paracrine TGF-beta signaling, activation of p38 MAPK, ERK1/2, and PI3K signal transduction pathways, and the transcriptional activity of NFAT5. PMID: 27628063
13. Aberrant DNA methylation of AKR1B1 could be potential screening markers of colorectal cancer. PMID: 27493446
14. -106T allele of AKR1B1 C-106T polymorphism may be associated with increased risk for essential hypertension in Chinese Han population. PMID: 27343777
15. These findings suggest a statistically significant association of AKR1B1 -106C>T polymorphism with retinopathy in North Indian patients PMID: 27640118
16. mRNA expression in macrophages correlates positively with M1 polarization, and depends on hyperglycemia PMID: 26873505
17. Meta-analysis shows that the AR rs759853 polymorphism may correlate with the susceptibility of DN. However, data do not support the association between this DNA variation and the progression of DN. PMID: 25885804
18. ALR C(-106)T polymorphism was not associated with an increased risk of Diabetic Retinopathy; subgroup analysis showed a genetic association between ALR C(-106)T polymorphism and the risk of Diabetic Retinopathy of type 1 Diabetes but not Diabetic Retinopathy of type 2 Diabetes(Meta-Analysis) PMID: 25722213
19. Higher expression of PLA2G2A, PTGS2, AKR1B1, AKR1C3 and ABCC4 was seen in 22-B endometriosis cells. PMID: 25446850
20. Data conclude that AKR1B1 and TM6SF1 may serve as candidate methylation biomarkers for early breast cancer detection. PMID: 25123395
21. L-idose is the best alternative to D-glucose in studies on aldose reductase. PMID: 25528584
22. role of the human aldose reductase AKR1B1 in prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue PMID: 24663124
23. One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK) pathways. PMID: 24567419
24. In type 2 diabetic patients with suboptimal glycaemic control, the z-4 allele of ALR2 (CA)n polymorphism was independently associated with increased susceptibility to cataracts. PMID: 24360973
25. prostaglandin F synthase activity of human and bovine aldo-keto reductases PMID: 23747692
26. Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53. PMID: 24474649
27. Aldose reductase gene may not be significantly associated with diabetic retinopathy in Chinese patients with type 2 diabetes mellitus. PMID: 24698671
28. These studies demonstrated sustained activation of Egr-1 with subsequent induction of its downstream target genes in diabetic mouse aortas and in high glucose-treated primary murine aortic endothelial cells expressing human aldose reductase. PMID: 24186862
29. molecular dynamics simulations were carried out to compute the electric field shift in human aldose reductase PMID: 23517423
30. A hydrogen bond stabilized active site tryptophan conformation restricts inhibitor access in AKR1B1 compared with the more open AKR1B10 active site. PMID: 24100137
31. AR inhibition regulates AKT/PI3K-dependent activation of forkhead transcription factor FOXO3a PMID: 23732517
32. these results show a novel role of AR in mediation of growth factor-induced colon Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a. PMID: 22978663
33. There were significantly lower mRNA and protein levels of AKR1B1 in cancerous tissues. PMID: 23146748
34. aldose reductase C-106T genetic polymorphism is not associated with essential hypertension PMID: 22561432
35. Overexpression of aldose reductase in cardiomyocytes leads to cardiac dysfunction with aging and in the setting of reduced fatty acid and increased glucose metabolism. PMID: 23029549
36. Data suggest that aldose reductase (AR) plays a mediatory role in ocular neovascularization as seen in diabetic retinopathy; inhibition of AR may have therapeutic potential in diabetic retinopathy. PMID: 22658411
37. analysis of the inhibition of aldose reductase by Gentiana lutea extracts PMID: 22844269
38. Site-directed mutagenesis of catalytic tetrad of AKR1B1, composed of Tyr, Lys, His and Asp, revealed triad of Asp43, Lys77 and His110, but not Tyr48, acts as a proton donor in most AKR activities, and is crucial for PGD(2) and PGF(2alpha) synthase activities PMID: 21306562
39. Molecular dynamics simulation has shown the versatile nature of water molecules in bridge H bonding during interaction. Occupancy and life time of water molecules depend on the type of cocrystallized ligand present in the structure. PMID: 22649481
40. AR has a role in regulating iNOS expression induced by TNF-alpha in cultured human mesangial cells, indicating the novel function of AR in glomerulonephritis. PMID: 21637955
41. The commonly reported association of AKR1B1 with diabetic retinopathy may be due to an association of the gene with younger age at onset of diabetes. PMID: 20424224
42. Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes. PMID: 21420193
43. Inhibition of AR prevented infiltration of blood cells, invasion, migration and formation of capillary like structures, and expression of blood vessels markers. PMID: 21409599
44. ALR2 over-expression is associated with an alteration in the balance between proliferation and apoptosis of epithelial cells in the mouse lens PMID: 21329682
45. the enzyme activity of AKR1B10 and AKR1B1 toward alpha, beta-unsaturated carbonyl compounds with cellular and dietary origins PMID: 21329684
46. findings suggest that AR plays an important role in the cellular response to oxidative stress by sequestering ROS and reactive aldehydes generated in keratinocytes PMID: 21182935
47. study shows that ALR C-106T polymorphism is not associated with carotid atherosclerosis in Chinese patients with type 2 diabetes. PMID: 21294693
48. activated hAR arises from oxidative modification of Cys-298, a residue near the nicotinamide binding pocket. PMID: 21084309
49. The human aldose reductase AKR1B1 is a highly functional PGF synthase responsible for PGF2alpha production in the human endometrium and a potential target for treatment of menstrual disorders. PMID: 20943776
50. AR is a potent regulator of TGF-beta1 induced expression of FN in human mesangial cells. PMID: 19847669

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HGNC: 381

OMIM: 103880

KEGG: hsa:231

STRING: 9606.ENSP00000285930

UniGene: Hs.521212