AKR1C4 Antibody

Code CSB-PA001545ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: Aldo-keto reductase family 1 member C4 antibody at 7μg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: HepG 2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 37 kDa
    Observed band size: 37 kDa

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA001545ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) AKR1C4 Polyclonal antibody
Uniprot No. P17516
Target Names AKR1C4
Alternative Names 3 alpha HSD1 antibody; 3-alpha-HSD1 antibody; 3-alpha-hydroxysteroid dehydrogenase type I antibody; AK1C4_HUMAN antibody; AKR1C4 antibody; Aldo keto reductase family 1 member C4 antibody; Aldo-keto reductase family 1 member C4 antibody; CDR antibody; Chlordecone reductase antibody; DD-4 antibody; DD4 antibody; Dihydrodiol dehydrogenase 4 antibody; HAKRA antibody; HSD3a antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Aldo-keto reductase family 1 member C4 protein (1-323AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Gene References into Functions
  1. the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells. PMID: 28259989
  2. Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency. PMID: 24189185
  3. In women only, SNPs in AKR1C4 reduced the likelihood of having exhibited paranoid ideation by circa 60%. PMID: 22356824
  4. Low progesterone levels and a cystine to serine change at position 145 in AKR1C4 gene are associated with manic/hypomanic irritability in males PMID: 21570127
  5. role of AKR1C4 in the metabolism of testosterone and progesterone via the 5beta-reductase pathway. PMID: 21521174
  6. Taken together, we conclude that the cell-type-specific expression of DD4 mRNA is regulated by vHNF-1-C. PMID: 12220531
  7. the expression level of DD4 mRNA is cooperatively regulated by the amounts of HNF-1 alpha, HNF-4 alpha and HNF-4 gamma. PMID: 12544512
  8. Impact of mirtazapine on the activity of a key neurosteroidogenic enzyme, the 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), and on the levels of neuroactive steroids in relation to clinical response in depression. PMID: 16344854
  9. Structure determination of human AKR1C4 and homology modelling of AKR1D1 followed by docking experiments were used to explore active site geometries. PMID: 19013211

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Involvement in disease 46,XY sex reversal 8 (SRXY8)
Subcellular Location Cytoplasm
Protein Families Aldo/keto reductase family
Tissue Specificity Liver specific.
Database Links

HGNC: 387

OMIM: 600451

KEGG: hsa:1109

STRING: 9606.ENSP00000263126

UniGene: Hs.567245

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