ALMS1 Antibody

Datasheet
Code CSB-PA844721LA01HU
Size US$299
Uniprot No. Q8TCU4
Image
  • Immunofluorescence staining of Hela cells with CSB-PA844721LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Protocols ELISA Protocol
Immunofluorescence (IF) Protocol
Immunogen Recombinant Human Alstrom syndrome protein 1 protein (889-1057AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IF; Recommended dilution: IF:1:50-1:200
Relevance Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Alstrom syndrome protein 1, ALMS1, KIAA0328
Immunogen Species Homo sapiens (Human)
Research Area Epigenetics and Nuclear Signaling
Target Names ALMS1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.
Involvement in disease Alstrom syndrome (ALMS)
Subcellular Location Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, cilium basal body, Cytoplasm, cytoskeleton, spindle pole
Tissue Specificity Expressed in all tissues tested including adipose and pancreas. Expressed by beta-cells of the islets in the pancreas (at protein level).
Database Links

HGNC: 428

OMIM: 203800

KEGG: hsa:7840

STRING: 9606.ENSP00000264448

UniGene: Hs.184720

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