AMBN Antibody

Code CSB-PA882061LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: Rat brain tissue
    All lanes: AMBN antibody at 4μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 49, 47 kDa
    Observed band size: 49 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AMBN Polyclonal antibody
Uniprot No.
Target Names
AMBN
Alternative Names
AMBN antibody; AMBN_HUMAN antibody; Ameloblastin (enamel matrix protein) antibody; Ameloblastin antibody
Raised in
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant Human Ameloblastin protein (264-387AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The AMBN Antibody (Product code: CSB-PA882061LA01HU) is Non-conjugated. For AMBN Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA882061LB01HU AMBN Antibody, HRP conjugated ELISA
FITC CSB-PA882061LC01HU AMBN Antibody, FITC conjugated
Biotin CSB-PA882061LD01HU AMBN Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the mineralization and structural organization of enamel.
Gene References into Functions
  1. Single nucleotide polymorphisms in the AMELX and AMBN genes may be genetic variants that contribute to developmental defects of enamel in primary dentition of Polish children. PMID: 28382465
  2. the calcium level was associated with genetic variations in AMELX, AMNB and ESRRB. AMELX and AMNB are involved in enamel mineralization. Mutations in both these genes are responsible for the amelogenesis imperfecta phenotype (OMIN), which supports their link with enamel alterations as well as enamel mineralization. PMID: 28395292
  3. these results indicate that AMBN enhances IL-1beta production in LPS-treated U937 cells through ERK1/2 phosphorylation and caspase-1 activation, suggesting that AMBN upregulates the inflammatory response in human macrophages and plays an important role in innate immunity. PMID: 28295583
  4. Association between caries experience (caries-free versus caries affected) depending on asthma status and SNPs was tested. Logistic regression showed an association between AMBN rs4694075 and caries experience. Ameloblastin is associated w/caries in asthmatic children. PMID: 24203249
  5. Protein interaction between Ambn and Psma3 can facilitate redistribution of ameloblastin domains within forming enamel. PMID: 26070558
  6. Authors perform an evolutionary analysis of mammalian AMBN sequences in order to predict functionally important sites of the protein and to identify candidate disease-associated mutations responsible for the protein function and identify AMBN as a candidate for amelogenesis imperfect in humans. PMID: 26223266
  7. Report shows for the first time that AMBN mutations cause non-syndromic human amelogenesis imperfecta and confirms that mouse models with disrupted Ambn function are valid. PMID: 24858907
  8. two genetic variants (rs2337359 upstream of TUFT1 and missense rs7439186 in AMBN) involved in gene-by-fluoride interactions. PMID: 25373699
  9. We found a trend for association between variation in AMBN and MIH in both cohorts, which may suggest that variation in the regulation of AMBN is a mechanism that leads to MIH. PMID: 23790503
  10. AMBN ribbons exhibited lengths ranging from tens to hundreds of nm. Deletion analysis and NMR spectroscopy revealed that N-terminal segment encoded by exon 5 comprises two short independently structured regions and plays a role in self-assembly of AMBN PMID: 23782691
  11. AMBN does not influence osteogenic activity in vitro under the conditions used PMID: 21761392
  12. Findings suggest a role for this protein in early bone formation and repair. PMID: 20854943
  13. ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin beta1 PMID: 21149578
  14. found to induce, directly and indirectly, signal transducer and activator of transcription (STAT) 1 and 2 and downstream factors in the interferon pathway PMID: 20831578
  15. The identification of a fibronectin-binding domain in ameloblastin might permit interesting applications for dental implantology. PMID: 20043904
  16. The frequently detected AMBN alterations in ameloblastomas are polymorphisms, which appear to be unrelated to the occurrence of ameloblastomas. PMID: 17331365
  17. a bipolar calcium-binding molecule [with] a possible role in protein-protein interactions PMID: 18353005
  18. Mutation of ameloblastin gene is associated with calcifying epithelial odontogenic tumor. PMID: 19661317

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Involvement in disease
Amelogenesis imperfecta 1F (AI1F)
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Protein Families
Ameloblastin family
Tissue Specificity
Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel.
Database Links

HGNC: 452

OMIM: 601259

KEGG: hsa:258

STRING: 9606.ENSP00000313809

UniGene: Hs.272396

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