AMT Antibody

Datasheet

Code	CSB-PA001684LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: A549 whole cell lysate, Mouse brain tissue All lanes: AMT antibody at 3.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 44, 38, 40, 42 kDa Observed band size: 44 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AMT Polyclonal antibody

Uniprot No.

P48728

Target Names

AMT

Alternative Names

Aminomethyltransferase (glycine cleavage system protein T) antibody; Aminomethyltransferase antibody; AMT antibody; GCE antibody; GCST antibody; GCST_HUMAN antibody; GCVT antibody; Glycine cleavage system T protein antibody; mitochondrial antibody; NKH antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Aminomethyltransferase, mitochondrial protein (180-260AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The AMT Antibody (Product code: CSB-PA001684LA01HU) is Non-conjugated. For AMT Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA001684LB01HU	AMT Antibody, HRP conjugated	ELISA
FITC	CSB-PA001684LC01HU	AMT Antibody, FITC conjugated
Biotin	CSB-PA001684LD01HU	AMT Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

The glycine cleavage system catalyzes the degradation of glycine.

Gene References into Functions

The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT PMID: 27362913
Data indicate no mutation was found in glycine cleavage system protein-H (GCSH) and suggest that mutations in both glycine decarboxylase (GLDC) and aminomethyltransferase (AMT) are the main cause of glycine encephalopathy in Malaysian population. PMID: 25231368
Two unique non-synonymous changes were identified in the AMT gene in patients with neural tube defects. PMID: 22171071
x-ray crystallographic structure of human T-protein of glycine cleavage system PMID: 16051266

Involvement in disease

Non-ketotic hyperglycinemia (NKH)

Subcellular Location

Mitochondrion.

Protein Families

GcvT family

Database Links

HGNC: 473

OMIM: 238310

KEGG: hsa:275

STRING: 9606.ENSP00000273588

UniGene: Hs.102

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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