ANXA11 Antibody

1. Both ANXA11 G38R protein and ANXA11 D40G protein showed a shorter half-life than ANXA11 wild type protein, while there was no difference between ANXA11 G38R protein and ANXA11 D40G protein. There was no visible insoluble substance in the NP-40 lysates for ANXA11 wild type protein, ANXA11 G38R protein and ANXA11 D40G protein. G38R and D40G mutations reduce the stability of ANXA11 protein. PMID: 30109997
2. Genetic variants in RAB23 and ANXA11 genes were associated with an increased risk of sarcoidosis-associated uveitis. PMID: 29416296
3. ANXA11 plays a critical role in regulating gastric cancer proliferation, migration, and invasion. PMID: 29306955
4. Data conclude that mutations in ANXA11 are associated with ALS and implicate defective intracellular protein trafficking in disease pathogenesis. PMID: 28469040
5. Letter: ANXA11 SNPs increase susceptibility to fibrosing sarcoiodosis in African Americans. PMID: 28079857
6. Review/Meta-analysis: ANXA11 SNP rs2573346 and rs2789679 conferred protection against sarcoidosis. SNP rs1049550 may be a risk factor for sarcoidosis in overall population. PMID: 27537711
7. ANXA11 rs1049550 and PPP1R15A rs557806 may improve the identification of mCRC patients sensitive to bevacizumab regimens, and further validation is required in large cohorts PMID: 27177629
8. These findings point to a role for the polymorphisms of ANXA11 in sarcoidosis in a Chinese Han population, and may be informative for future genetic studies on sarcoidosis. PMID: 25056970
9. findings suggest that AnxA11 maintains architectural and functional features of the ERES by coordinating with ALG-2 to stabilize Sec31A at the ERES. PMID: 25540196
10. the associations of Anxa11 with Ca(2+)-regulated exocytosis, cytokinesis, sex differentiation, autoimmune diseases, thrombolysis and cancers are summarized--{REVIEW} PMID: 24508622
11. Annexin A11 rs1049550*T allele exerts a significant protective effect on sarcoidosis susceptibility. PMID: 24032725
12. LIFR rs3729740 and possibly ANXA11 rs1049550 may be useful as biomarkers for predicting whether metastatic colorectal cancer patients are sensitive to relevant target regimens, although further validation in large cohorts is needed. PMID: 23579219
13. ANXA11 SNPs are associated with sarcoidosis in African Americans. PMID: 23151485
14. ANXA11 rs1049550 single nucleotide polymorphism is the susceptibility marker in sarcoidosis, at least in Caucasians. PMID: 21562576
15. Data confirm the strong association between variations in ANXA11 and sarcoidosis and support the hypothesis that ANXA11 represents a strong genetic risk factor for sarcoidosis. PMID: 20805159
16. analysis of the sarcoidosis-associated variant of annexin A11 PMID: 20093723
17. Pro/Gly/Tyr/Ala-rich hydrophobic region in AnxN masked the Ca(2+)-dependently exposed hydrophobic surface of ALG-2. PMID: 11883939
18. The penta-EF-hand domain of ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca2+-dependent manner. PMID: 12445460
19. calcium- and cell cycle-dependent association with the nuclear envelope PMID: 12601007
20. annexin XI associates with the mitotic spindles and might play a role in cell division PMID: 12805373
21. Annexin 11-depleted cells failed to complete cytokinesis and died by apoptosis, demonstrating an essential role for annexin 11. PMID: 15197175
22. The strongest association signal maps to the ANXA11 (annexin A11) gene on chromosome 10q22.3. PMID: 19165924
23. Immunohistochemistry analyses indicated that annexin A11 immunointensity inversely correlated with HMOX1 immunoreactivity in 142 ovarian cancer patients. PMID: 19484149

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HGNC: 535

OMIM: 602572

KEGG: hsa:311

STRING: 9606.ENSP00000265447

UniGene: Hs.530291