AP4B1 Antibody

Code CSB-PA897585LA01HU
Size US$166
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  • Western blot
    All lanes: AP4B1 antibody at 3μg/ml
    Lane 1: HepG2 whole cell lysate
    Lane 2: U251 whole cell lysate
    Lane 3: LO2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 84, 35 kDa
    Observed band size: 84 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA897585LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA897585LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AP4B1 Polyclonal antibody
Uniprot No.
Target Names
AP4B1
Alternative Names
AP4B1AP-4 complex subunit beta-1 antibody; AP-4 adaptor complex subunit beta antibody; Adaptor-related protein complex 4 subunit beta-1 antibody; Beta subunit of AP-4 antibody; Beta4-adaptin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human AP-4 complex subunit beta-1 protein (201-500AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The AP4B1 Antibody (Product code: CSB-PA897585LA01HU) is Non-conjugated. For AP4B1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA897585LB01HU AP4B1 Antibody, HRP conjugated ELISA
FITC CSB-PA897585LC01HU AP4B1 Antibody, FITC conjugated
Biotin CSB-PA897585LD01HU AP4B1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.
Gene References into Functions
  1. Novel homozygous 2-bp deletion in AP4B1 was found in siblings with intellectual disability and spastic tetraplegia. PMID: 24781758
  2. Data suggest that AP4B1 mutations cause spastic paraplegia type 47 and should be considered in early onset spastic paraplegia with intellectual disability. PMID: 22290197
Involvement in disease
Spastic paraplegia 47, autosomal recessive (SPG47)
Subcellular Location
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Protein Families
Adaptor complexes large subunit family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 572

OMIM: 607245

KEGG: hsa:10717

STRING: 9606.ENSP00000256658

UniGene: Hs.515048

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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