APC2 Antibody, FITC conjugated

Code CSB-PA001895LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) APC2 Polyclonal antibody
Uniprot No.
Target Names
APC2
Alternative Names
Adenomatous polyposis coli protein 2 antibody; Adenomatous polyposis coli protein-like antibody; APC-like antibody; apc2 antibody; APC2_HUMAN antibody; APCL antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Adenomatous polyposis coli protein 2 protein (2011-2221AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1.
Gene References into Functions
  1. It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains. PMID: 30018294
  2. double knockdown of APC2 and miR-4326 promoted lung cancer cell proliferation, confirming that miR-4326 promoted lung cancer cell proliferation by inhibiting APC2. PMID: 29101731
  3. APC2 3'-UTR is targeted by hsa-miR-11181. PMID: 29111205
  4. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium PMID: 27694902
  5. Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2. PMID: 27068743
  6. miR-939 functioned as a potential tumor promoter by regulating the Wnt/beta-catenin signal pathway through direct suppression of APC2 expression. PMID: 25960217
  7. We report that APC-2 gene is hypermethylated in both RB tumor samples and Y79 cells. Reduced APC-2 lead to increased Wnt signaling pathway protein, beta-catenin suggesting tumor suppressive role of APC-2 gene. PMID: 25207834
  8. APCL uses the 15 amino acid repeats region of APC to target beta-catenin for degradation. PMID: 23840886
  9. These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling. PMID: 22513088
  10. Familial adenomatous polyposis with adenomatous polyposis coli gene mutation at codon 1309 entails a risk of a more aggressive phenotype; early colectomy may be indicated in children harboring this gene mutation. PMID: 18157572

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Involvement in disease
Sotos syndrome 3 (SOTOS3)
Subcellular Location
Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region.
Protein Families
Adenomatous polyposis coli (APC) family
Tissue Specificity
Widely expressed (at protein level). Specifically expressed in the CNS.
Database Links

HGNC: 24036

OMIM: 612034

KEGG: hsa:10297

STRING: 9606.ENSP00000233607

UniGene: Hs.446376

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