APIP Antibody

Code CSB-PA001906GA01HU
Size US$685
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Product Details

Uniprot No. Q96GX9
Target Names APIP
Alternative Names Apaf1 Interacting Protein antibody; APAF1-interacting protein antibody; APIP antibody; APIP2 antibody; CG129 antibody; CGI 29 antibody; CGI29 antibody; dJ179L10.2 antibody; MMRP19 antibody; Monocyte/macrophage protein 19 antibody; MTNB_HUMAN antibody; MTRu 1 P dehydratase antibody; MTRu-1-P dehydratase antibody; Probable methylthioribulose 1 phosphate dehydratase antibody; Probable methylthioribulose-1-phosphate dehydratase antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human APIP
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
Gene References into Functions
  1. Results suggest that APIP stimulates cell proliferation via ERBB3, acting in conjunction with ERBB2, in gastric cancer cells. PMID: 26942872
  2. APIP/MtnB functions as a cell death inhibitor independently of its MtnB enzyme activity for apoptosis induced by either hypoxia or etoposide, but dependently for caspase-1-induced pyroptosis PMID: 24367089
  3. these results confirm the involvement of APIP in the methionine salvage pathway, which plays a key role in many biological functions like cancer, apoptosis, microbial proliferation and inflammation. PMID: 23285211
  4. human APIP was overproduced in Escherichia coli, purified and crystallized. An X-ray diffraction data set was collected to 2.40 A resolution PMID: 23192037
  5. A polymorphism associated with reduced expression of a putative methionine salvage pathway dehydratase, apoptotic protease activating factor 1 (APAF1)-interacting protein (APIP), was associated with increased caspase-1-mediated cell death in Salmonella. PMID: 22837397
  6. The down-regulation of APIP and UACA expression suggests that the threshold to activate the apoptosome apparatus may be decreased in non-small cell lung cancer cells. PMID: 22407486
  7. APIP functions to inhibit muscle ischemic damage by binding to Apaf-1 in the Apaf-1/caspase-9 apoptosis pathway. PMID: 15262985

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Subcellular Location Cytoplasm
Protein Families Aldolase class II family, MtnB subfamily
Tissue Specificity Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.
Database Links

HGNC: 17581

OMIM: 612491

KEGG: hsa:51074

STRING: 9606.ENSP00000379133

UniGene: Hs.447794

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