APOA1BP Antibody

Code CSB-PA165586
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA165586(APOA1BP Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA165586(APOA1BP Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
NAXE
Alternative Names
NAXE antibody; AIBP antibody; APOA1BP antibody; YJEFN1 antibody; NAD(P)H-hydrate epimerase antibody; EC 5.1.99.6 antibody; Apolipoprotein A-I-binding protein antibody; AI-BP antibody; NAD(P)HX epimerase antibody; YjeF N-terminal domain-containing protein 1 antibody; YjeF_N1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide of Human APOA1BP
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
Gene References into Functions
  1. NAXE gene mutations are associated with early-onset progressive encephalopathy. PMID: 30022751
  2. Study shows a homozygous mutation in the APOA1BP is associated with a lethal infantile leukoencephalopathy.This is the first report of a defect in the nicotinamide nucleotide repair system in humans. PMID: 27122014
  3. NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood PMID: 27616477
  4. AIBp contributes to mitotic entry and bipolar spindle assembly. PMID: 26114227
  5. AIBP accelerates cholesterol efflux from endothelial cells to HDL and thereby regulates angiogenesis PMID: 23719382
  6. Taken together, the current study demonstrates that APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver. PMID: 17521614

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Involvement in disease
Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy (PEBEL)
Subcellular Location
Mitochondrion. Secreted.
Protein Families
NnrE/AIBP family
Tissue Specificity
Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level).
Database Links

HGNC: 18453

OMIM: 608862

KEGG: hsa:128240

STRING: 9606.ENSP00000357218

UniGene: Hs.528320

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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