ARAP1 Antibody

Datasheet

Code	CSB-PA856998LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA856998LA01HU at dilution of 1:100 Immunofluorescent analysis of PC-3 cells using CSB-PA856998LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ARAP1 Polyclonal antibody

Uniprot No.

Q96P48

Target Names

ARAP1

Alternative Names

2410002L19Rik antibody; ANK repeat and PH domain-containing protein 1 antibody; ARAP 1 antibody; Arap1 antibody; ARAP1_HUMAN antibody; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domains containing protein 1 antibody; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1 antibody; Arf-GAP with Rho-GAP domain antibody; CENT D2 antibody; Centaurin delta 2 antibody; Centaurin delta2 antibody; Centaurin-delta-2 antibody; CENTD 2 antibody; CENTD2 antibody; Cnt d2 antibody; Cnt-d2 antibody; Cntd2 antibody; KIAA0782 antibody; MGC176140 antibody; mKIAA0782 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 protein (69-344AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ARAP1 Antibody (Product code: CSB-PA856998LA01HU) is Non-conjugated. For ARAP1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA856998LB01HU	ARAP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA856998LC01HU	ARAP1 Antibody, FITC conjugated
Biotin	CSB-PA856998LD01HU	ARAP1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5.

Gene References into Functions

Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression. PMID: 28132686
Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population. PMID: 25749274
The proinsulin-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets. PMID: 24439111
a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1/5 pathway. PMID: 22573888
Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II. PMID: 22357923
Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin release. PMID: 21267535
ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking PMID: 21275903
PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells. PMID: 20554524
ARAP1 acts primarily on Arf6 in vivo. PMID: 18003747
ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death. PMID: 18165900
ARAP1 controls the late steps of the endocytic trafficking of the EGF-R PMID: 18764928
ARAP1 regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation PMID: 18939958
Data suggest that ARAP1 is recruited to membranes independently of PtdIns(3,4,5)P(3), the subsequent production of which triggers enzymatic activity. PMID: 19666464

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Subcellular Location

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.

Tissue Specificity

Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.

Database Links

HGNC: 16925

OMIM: 606646

KEGG: hsa:116985

STRING: 9606.ENSP00000377233

UniGene: Hs.503165

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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