ARHGAP1 Antibody

1. identified ARHGAP1, which is a negative regulator of CDC42, as a novel, direct target of miR-130b PMID: 28748534
2. to complete invasion of the endothelium, staphylococci reorient recycling endocytic vesicles to recruit Cdc42GAP. PMID: 27311480
3. we identified novel associations in WLS , ARHGAP1 , and 5' of MEF2C ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD compared to the GWAS SNPs. PMID: 27616567
4. study shows that HMHA1 acts as a RhoGAP to regulate GTPase activity, cytoskeletal remodeling and cell spreading, which are crucial functions in normal hematopoietic and cancer cells PMID: 24086303
5. The interaction of RhoGap protein stabilizes the tetrameric conformation of p53 and enhances its DNA-binding activity, thereby inducing cell-cycle arrest and apoptosis. PMID: 23684608
6. In PC3 cells, ARHGAP21 presented GAP activity for RhoA and RhoC and induced changes in cell morphology. Moreover, its silencing altered the expression of genes involved in cell proliferation and cytoskeleton organization PMID: 23200924
7. RhoGAP Stard13 temporally and spatially regulates Rho activity in the developing pancreas to ensure that morphogenesis and establishment of tissue architecture are coordinated with organ growth. PMID: 23175628
8. Rho proteins and ROK play a pivotal role in this signaling cascade PMID: 21051874
9. PA and Rap1 cooperatively regulate RA-RhoGAP activity for promoting neurite outgrowth. PMID: 21169361
10. Mutation of three residues of CDC42GAP involved in specific interactions of CDC42GAP with switch domain residues of Cdc42, as well as individual mutations of each of these residues, yields GAPs that are defective in stimulating GTP hydrolysis. PMID: 12501193
11. phosphorylation of Y1214 on VEGFR2 is required to trigger the sequential activation of Cdc42 and SAPK2/p38 and to drive the SAPK2/p38-mediated actin remodeling in stress fibers in endothelial cells exposed to VEGF PMID: 14724572
12. lipopolysaccharide-induced activation of the Rho family GTPase Cdc42, and we show its activation in the human neutrophil to be mediated by a p38 mitogen-activated protein kinase-dependent mechanism. PMID: 15262974
13. CDC42GAP was identified as a counter-regulatory mediator for tubule formation. PMID: 18060510
14. The NR5A1 gene expression was activated in mesenchymal stem cells by siRNA directed against RhoGAP (ARHGAP26). PMID: 18579725
15. two potential interaction partners of Prx6: the calcium-activated cysteine endopeptidase calpain and the p50RhoGAP protein of the family of Sec14-like proteins. PMID: 18619034
16. Results show that phorbol-ester-induced activation of protein kinases C and D stimulates association of DLC1 with 14-3-3 adaptor proteins, inhibiting RhoGAP activity and blocking nucleocytoplasmic transfer. PMID: 19066281

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HGNC: 673

OMIM: 602732

KEGG: hsa:392

STRING: 9606.ENSP00000310491

UniGene: Hs.138860