ARHGAP22 Antibody

Code CSB-PA040133
Size US$100
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Product Details

Uniprot No.
Target Names
ARHGAP22
Alternative Names
ARHGAP22 antibody; RHG22_HUMAN antibody; Rho GTPase activating protein 2 antibody; Rho GTPase activating protein 22 antibody; Rho GTPase-activating protein 22 antibody; Rho type GTPase activating protein 22 antibody; Rho-type GTPase-activating protein 22 antibody; RhoGAP2 antibody; RhoGap22 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the C-terminal region of Human ARHGAP22.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.
Gene References into Functions
  1. There is a significant association between single nucleotide polymorphism in the ARHGAP22 gene and diabetic retinopathy risk in a Han Chinese population PMID: 28544509
  2. a weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode PMID: 22952583
  3. The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling. PMID: 21926414
  4. Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin PMID: 21969604
  5. We identified a genetic association for susceptibility to retinopathy in 5 novel chromosomal regions and PLXDC2 and ARHGAP22, the latter 2 of which are genes implicated in endothelial cell angiogenesis and increased capillary permeability. PMID: 21310492

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Subcellular Location
Cytoplasm. Nucleus.
Database Links

HGNC: 30320

OMIM: 610585

KEGG: hsa:58504

STRING: 9606.ENSP00000249601

UniGene: Hs.655672

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