Name: ARHGAP24 Antibody
Brand: CUSABIO
SKU: CSB-PA002025GA01HU

Product Details

Uniprot No.	Q8N264
Target Names	ARHGAP24
Alternative Names	ARHGAP24 antibody; FILGAP antibody; Rho GTPase-activating protein 24 antibody; Filamin-A-associated RhoGAP antibody; FilGAP antibody; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa antibody; RC-GAP72 antibody; Rho-type GTPase-activating protein 24 antibody; RhoGAP of 73 kDa antibody; Sarcoma antigen NY-SAR-88 antibody; p73RhoGAP antibody
Raised in	Rabbit
Species Reactivity	Human,Mouse,Rat,Dog,Zebrafish
Immunogen	Human ARHGAP24
Immunogen Species	Homo sapiens (Human)
Isotype	IgG
Purification Method	Antigen Affinity purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications	ELISA,WB,IHC
Protocols	ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function	Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
Gene References into Functions	MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24 PMID: 29019371 ARHGAP24 plays a unique role in renal cell carcinoma progression as a tumor repressor. PMID: 27385097 this study clearly provided evidence that FilGAP, as well as IDH1 status, may be useful for predicting the behavior of astrocytomas. In addition, the FilGAP/Rac1 axis may serve as an important regulator of tumor progression in GBMs, probably through alteration of cell morphology. PMID: 27790861 ARHGAP24 may regulate pseudopod formation downstream of activated ARF6 in MDA-MB-231 human breast carcinoma cells. PMID: 28870903 Study identified FilGAP as a negative regulator of lymphocyte polarization and migration and shows that FilGAP may suppress lamellae formation at the front of migrating lymphocyte. PMID: 27130700 Src family tyrosine kinase signaling may regulate FilGAP through association with RBM10 PMID: 26751795 FilGAP may contribute to change in cell motility of B-lymphocytes and in addition, its expression appears to be useful for predicting the behavior of B-cell lymphoma, in particular follicular lymphoma. PMID: 25641953 study suggests that Arf6 and phosphorylation of FilGAP may regulate FilGAP, and phosphorylation of Ser-402 may play a role in the regulation of cell spreading on fibronectin PMID: 26359494 Polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants. PMID: 21823009 FilGAP may function as a mediator of the regulation of Rac by Arf6. PMID: 24526684 Data indicate that phosphorylation of FilGAP by ROCK appears to promote amoeboid morphology. PMID: 23097497 Consistent with structural predictions, strain increases beta-integrin binding to FLNA, whereas it causes FilGAP to dissociate from FLNA, providing a direct and specific molecular basis for cellular mechanotransduction PMID: 21926999 sequencing of the ARHGAP24 gene in patients with focal segmental glomerulosclerosis (FSGS) identified a mutation that impaired its Rac1-GAP activity and was associated with disease in a family with FSGS PMID: 21911940 p73, a vascular cell-specific GTPase-activating protein, is an important modulator of angiogenesis PMID: 15302923 propose that RC-GAP72 affects cellular morphology by targeting activated Cdc42 and Rac1 GTPases to specific subcellular sites, triggering local morphological changes PMID: 15611138 FilGAP plays a role in protecting cells against force-induced apoptosis. PMID: 19144823 Point mutagenesis revealed that disruption of the FLNa-FilGAP interface perturbs cell spreading. FilGAP does not bind FLNa homologs FLNb or FLNc establishing the importance of this interaction to the human FLNa mutations PMID: 19293932 Show More Hide All
Subcellular Location	Cytoplasm, cytoskeleton, Cell junction, adherens junction, Cell junction, focal adhesion, Cell projection
Tissue Specificity	Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells.
Database Links	HGNC: 25361 OMIM: 610586 KEGG: hsa:83478 STRING: 9606.ENSP00000378611 UniGene: Hs.444229

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Code	CSB-PA002025GA01HU
Size	US$685
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ARHGAP24 Antibody

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