ART1 Antibody

Code CSB-PA002155LA01HU
Size US$166
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  • IHC image of CSB-PA002155LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ART1 Polyclonal antibody
Uniprot No.
Target Names
ART1
Alternative Names
ART1GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 antibody; EC 2.4.2.31 antibody; ADP-ribosyltransferase C2 and C3 toxin-like 1 antibody; ARTC1 antibody; Mono(ADP-ribosyl)transferase 1 antibody; CD antigen CD296 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 protein (46-142AA )
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ART1 Antibody (Product code: CSB-PA002155LA01HU) is Non-conjugated. For ART1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA002155LB01HU ART1 Antibody, HRP conjugated ELISA
FITC CSB-PA002155LC01HU ART1 Antibody, FITC conjugated
Biotin CSB-PA002155LD01HU ART1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has ADP-ribosyltransferase activity toward GLP1R.
Gene References into Functions
  1. Our data suggest that ART1 could regulate EMT by regulating the RhoA/ROCK1/AKT/beta-catenin pathway and its downstream factors (snail1, vimentin, N-cadherin and E-cadherin) and that it therefore plays an important role in the progression of colon carcinoma. PMID: 27277835
  2. up-regulation of ART1 expression is associated with the aggressiveness of glioma. PMID: 27466078
  3. Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway PMID: 26847718
  4. The altered function and expression of P2X7 and ART1 in the human CD39+ Treg or CD39- Treg cells could participate in the resistance against cell death induced by ATP or NAD. PMID: 26307000
  5. This study provides evidence that ARTC1 is activated during the endoplasmic-reticulum stress response, which results in acute ADP-ribosylation of GRP78/BiP paralleling translational inhibition. PMID: 25292337
  6. ADP-ribosylation of HNP-1 appears to be primarily an activity of ART1 and occurs in inflammatory conditions and disease PMID: 16627471
  7. ADPRT Ala762Val polymorphism may play a role in the etiology of squamous cell carcinoma of the head and neck or in linkage disequilibrium with other untyped protective alleles. PMID: 17614107

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Subcellular Location
Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
Protein Families
Arg-specific ADP-ribosyltransferase family
Database Links

HGNC: 723

OMIM: 601625

KEGG: hsa:417

STRING: 9606.ENSP00000250693

UniGene: Hs.382188

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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