ASCC1 Antibody

Datasheet

Code	CSB-PA002196LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, Jurkat whole cell lysate, Mouse heart tissue, Mouse liver tissue, Mouse lung tissue, Mouse kidney tissue, Mouse brain tissue, Mouse stomach tissue All lanes: ASCC1 antibody at 2.7µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 46, 42 kDa Observed band size: 46 kDa Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA002196LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ASCC1 Polyclonal antibody

Uniprot No.

Q8N9N2

Target Names

ASCC1

Alternative Names

Activating signal cointegrator 1 complex subunit 1 antibody; ASC-1 complex subunit p50 antibody; ASC1 complex subunit p50 antibody; ASC1p50 antibody; ASCC1 antibody; ASCC1_HUMAN antibody; CGI 18 antibody; RP11-150D20.4 antibody; Trip4 complex subunit p50 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Activating signal cointegrator 1 complex subunit 1 protein (1-315AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ASCC1 Antibody (Product code: CSB-PA002196LA01HU) is Non-conjugated. For ASCC1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA002196LB01HU	ASCC1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002196LC01HU	ASCC1 Antibody, FITC conjugated
Biotin	CSB-PA002196LD01HU	ASCC1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.

Gene References into Functions

Our patient was also found to have a homozygous frameshift variant (c.157dupG, p.Glu53Glyfs*19) in ASCC1 , thereby representing the second known case. This confirms ASCC1 involvement in a severe neuromuscular disease lying within the spinal muscular atrophy or primary muscle disease spectra PMID: 28218388
ASCC1 inhibits NF-kappaB activation and a truncated and inactive variant of ASCC1 is associated with a more severe disease, which could have clinical value for assessing the progression and prognosis of Rheumatoid Arthritis. PMID: 26503956
Three major genes, MSR1, ASCC1, and CTHRC1 were associated with Barrett esophagus/esophageal adenocarcinoma PMID: 21791690
Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1. PMID: 19074642

Involvement in disease

Barrett esophagus (BE); Spinal muscular atrophy with congenital bone fractures 2 (SMABF2)

Subcellular Location

Nucleus. Nucleus speckle.

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 24268

OMIM: 614215

KEGG: hsa:51008

STRING: 9606.ENSP00000339404

UniGene: Hs.500007

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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