ASCL2 Antibody

1. this study shows that Ascl2 level was higher in peripheral blood mononuclear cells from Sjogren's syndrome patients compared with those from healthy controls PMID: 28728856
2. A novel HIF-1alpha/Ascl2/miR-200b regulatory feedback circuit in modulating EMT-MET plasticity of CRC cells, which could serve as a possible therapeutic target. PMID: 28899657
3. WiNTRLINC1 interacts with TCF4/beta-catenin to mediate the juxtaposition of its promoter with the regulatory regions of ASCL2. PMID: 27292638
4. Ascl2 over-expression is associated with colorectal neoplasms. PMID: 26307678
5. expression of ASCL2 may identify an aggressive subgroup in lung squamous cell carcinoma PMID: 26483561
6. SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis. PMID: 25866254
7. SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775
8. ASCL2 gene expression is regulated by miR-200a/b/c, miR-141 and miR429 levels in colon cancer. PMID: 25371200
9. Ascl2 directly initiates follicular T-helper cell development PMID: 24463518
10. These results suggest that ASCL2 might play an important role in gastric tumor growth and chemoresistance. PMID: 23181270
11. Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells PMID: 22384170
12. a stem cell specific transcription signature promoted by ASCL2 has been identified to be upregulated in a subset of liver metastases, those characterised by an 11p15.5 gain PMID: 20479215
13. These findings suggest that increased protein levels and DNA binding of USF1 and USF2 mediate the inhibitory effects of hypoxia and of Mash-2 on CYP19 gene expression in human placenta PMID: 12917334
14. These results suggest that PACE4 expression is down-regulated by Hash-2/Mash-2 in both human and rat placenta and that many bioactive proteins might be regulated by PACE4 activity. PMID: 14561729
15. ascl2 is a putative regulator of proliferation that is overexpressed in intestinal neoplasia PMID: 16568095
16. Negative expression of HASH2 in complete hydatidiform moles (CM) but positive expression in malignant tumors suggests the presence of a specific mechanism for inactivation of the HASH2 gene in CM and reactivation in invasive moles or choriocarcinoma PMID: 17165436

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HGNC: 739

OMIM: 601886

KEGG: hsa:430

STRING: 9606.ENSP00000332293

UniGene: Hs.152475