ASCL2 Antibody

Code CSB-PA010204
Size US$100
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Product Details

Uniprot No.
Target Names
Alternative Names
ASCL2 antibody; BHLHA45 antibody; HASH2Achaete-scute homolog 2 antibody; ASH-2 antibody; hASH2 antibody; Class A basic helix-loop-helix protein 45 antibody; bHLHa45 antibody; Mash2 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the Internal region of Human Mash2.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
Gene References into Functions
  1. this study shows that Ascl2 level was higher in peripheral blood mononuclear cells from Sjogren's syndrome patients compared with those from healthy controls PMID: 28728856
  2. A novel HIF-1alpha/Ascl2/miR-200b regulatory feedback circuit in modulating EMT-MET plasticity of CRC cells, which could serve as a possible therapeutic target. PMID: 28899657
  3. WiNTRLINC1 interacts with TCF4/beta-catenin to mediate the juxtaposition of its promoter with the regulatory regions of ASCL2. PMID: 27292638
  4. Ascl2 over-expression is associated with colorectal neoplasms. PMID: 26307678
  5. expression of ASCL2 may identify an aggressive subgroup in lung squamous cell carcinoma PMID: 26483561
  6. SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis. PMID: 25866254
  7. SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775
  8. ASCL2 gene expression is regulated by miR-200a/b/c, miR-141 and miR429 levels in colon cancer. PMID: 25371200
  9. Ascl2 directly initiates follicular T-helper cell development PMID: 24463518
  10. These results suggest that ASCL2 might play an important role in gastric tumor growth and chemoresistance. PMID: 23181270
  11. Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells PMID: 22384170
  12. a stem cell specific transcription signature promoted by ASCL2 has been identified to be upregulated in a subset of liver metastases, those characterised by an 11p15.5 gain PMID: 20479215
  13. These findings suggest that increased protein levels and DNA binding of USF1 and USF2 mediate the inhibitory effects of hypoxia and of Mash-2 on CYP19 gene expression in human placenta PMID: 12917334
  14. These results suggest that PACE4 expression is down-regulated by Hash-2/Mash-2 in both human and rat placenta and that many bioactive proteins might be regulated by PACE4 activity. PMID: 14561729
  15. ascl2 is a putative regulator of proliferation that is overexpressed in intestinal neoplasia PMID: 16568095
  16. Negative expression of HASH2 in complete hydatidiform moles (CM) but positive expression in malignant tumors suggests the presence of a specific mechanism for inactivation of the HASH2 gene in CM and reactivation in invasive moles or choriocarcinoma PMID: 17165436

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Subcellular Location
Tissue Specificity
Expressed specifically in the extravillous trophoblasts of the developing placenta.
Database Links

HGNC: 739

OMIM: 601886

KEGG: hsa:430

STRING: 9606.ENSP00000332293

UniGene: Hs.152475

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