AVIL Antibody

Datasheet

Code	CSB-PA002464LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HepG2 whole cell lysate All lanes: AVIL antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 93, 92 kDa Observed band size: 93 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AVIL Polyclonal antibody

Uniprot No.

O75366

Target Names

AVIL

Alternative Names

Actin binding protein DOC 6 antibody; Actin binding protein DOC6 antibody; Advil antibody; Advillin antibody; AVIL antibody; AVIL_HUMAN antibody; DOC 6 antibody; DOC6 antibody; p92 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Advillin protein (623-819AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The AVIL Antibody (Product code: CSB-PA002464LA01HU) is Non-conjugated. For AVIL Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA002464LB01HU	AVIL Antibody, HRP conjugated	ELISA
FITC	CSB-PA002464LC01HU	AVIL Antibody, FITC conjugated
Biotin	CSB-PA002464LD01HU	AVIL Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly.

Gene References into Functions

NMR structure of the C-terminal headpiece subdomains of advillin. Evaluation of F-actin-binding requirements. PMID: 15096633
Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. PMID: 18022635

Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell junction, focal adhesion. Cell projection, neuron projection. Cell projection, axon.

Protein Families

Villin/gelsolin family

Tissue Specificity

Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. Expressed in podocytes (at protein level).

Database Links

HGNC: 14188

OMIM: 613397

KEGG: hsa:10677

STRING: 9606.ENSP00000257861

UniGene: Hs.584854

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