AZIN1 Antibody

1. Using high-resolution (1)H-NMR spectroscopy, we demonstrated that a long-looped quadruplex in the AZIN1 mRNA co-exists in salt-dependent equilibria with a hairpin structure. PMID: 30063205
2. e in vivo experiment confirmed that this RNA editing confers higher capacity of tumor migration as well. In conclusion, antizyme inhibitor 1 RNA editing and its involvement in tumorigenesis of non-small-cell lung cancer pave a new way for potential clinical management of non-small-cell lung cancer. PMID: 28849733
3. AzI1 fulfils an essential regulatory function in polyamine homeostasis and cell proliferation. PMID: 25813938
4. Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN). PMID: 26305948
5. This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation. PMID: 15670771
6. edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 PMID: 23291631
7. minor allelic SNP variant in 12th exon of AZIN1 associated with slower rates of fibrosis progression favors expression of novel splice form, AZIN1 SV2, that inhibits expression of fibrogenic genes in hepatic stellate cells. PMID: 21837750
8. AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function. PMID: 21931692
9. SNP rs2679757 in the AZIN1 gene is associated with the risk of HBV-related liver cirrhosis in Chinese patients. PMID: 21586232
10. Decreased ornithine decarboxylase is associated with prostate cancer. PMID: 20215859

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HGNC: 16432

OMIM: 607909

KEGG: hsa:51582

STRING: 9606.ENSP00000321507

UniGene: Hs.459106