BACH2 Antibody

1. The authors show that the timed repression of BACH2 through IL-2-mediated ERK/ELK1 signalling pathway directs plasma cell lineage commitment. PMID: 29129929
2. The epithelial-mesenchymal transition (EMT) pathway was also influenced by miR-130a-3p down-regulation. In conclusion, miR-130a-3p could bind to BACH2, inhibit nasopharyngeal carcinoma cell abilities, and promote cell apoptosis. PMID: 28487475
3. Ikaros regulates expression of the BCL6/BACH2 axis in acute lymphoblastic leukemia cells. PMID: 28030830
4. Data show that BACH2 and STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence. PMID: 28887441
5. BACH2 downregulation contributes to constitutive activation of the nuclear factor-kappaB. PMID: 28256087
6. BACH2 haploinsufficiency causing a syndrome of immune deficiency and autoimmunity is described in two families. Affected subjects had lymphocyte-maturation defects that caused immunoglobulin deficiency and intestinal inflammation. PMID: 28530713
7. In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2. PMID: 28592433
8. we developed a CRISPR-Cas9-based tool for specific DNA methylation consisting of deactivated Cas9 (dCas9) nuclease and catalytic domain of the DNA methyltransferase DNMT3A targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation of a wider promoter region of the target loci IL6ST and BACH2 decreased their expression PMID: 26969735
9. genetic association studies in population in the United Kingdom: Data suggest that an SNP in BACH2 (rs3757247) is associated with autoimmune Addison's disease and with polyglandular autoimmune syndrome type 2. These findings were replicated in a Norwegian validation cohort. PMID: 27680876
10. The shift in the CSDs by heme binding suggested that heme binding causes Bach2(331-520) to adopt a more compact conformation. In addition, heme binding to the CP-motif could reduce the flexibility of Bach2(331-520) Consequently, the five-coordinated heme binding destabilizes Bach2(331-520), by reducing the flexibility of the polypeptide chain. PMID: 27206783
11. The study identifies a strong association of Coeliac Disease with a network of BACH2 regulated genes, supporting emerging evidence of an important role of BACH2 in the regulation of T cell differentiation and prevention of autoimmune disease. PMID: 26444573
12. The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either Vogt-Koyanagi-Harada syndrome and Behcet's disease in our investigated Chinese Han population. PMID: 25873652
13. Gene expression analysis revealed that three gene BACH2, PTGER4 and ZFP36L1, are down-regulated in MS patients' blood cells compared to healthy subjects. PMID: 25670004
14. These observations suggested that the unstructured region of Bach2 is important for heme binding, and consequently for its functional regulation PMID: 25444856
15. A restored BACH2 expression in BACH2-silenced gastric cancer cell lines, and knockdown of BACH2 using short hairpin RNA (i.e. RNA interference) increased cell proliferation in gastric cancer cells. PMID: 24858026
16. The type 1 diabetes candidate gene BACH2 regulates proinflammatory cytokine-induced apoptotic pathways in pancreatic beta-cells by crosstalk with another candidate gene, PTPN2, and activation of JNK1 and BIM. PMID: 24608439
17. The dynamics of Bach2 expression in response to DNA damage shows that it is a highly sensitive responder to transcription-blocking DNA lesions. PMID: 24075570
18. BACH2 expression level is a promising predictor of prognosis for diffuse large B cell lymphoma. PMID: 24450488
19. Our study clearly demonstrated that BACH2 is a susceptibility gene for GD in the Chinese Han population PMID: 24346624
20. Lower levels of BACH2 is associated with drug resistance in mantle cell lymphoma. PMID: 23936317
21. our data suggest that BACH2 may play an essential role for somatic hypermutation of the Ig gene in B-cell lymphoma PMID: 23865571
22. This study provides robust evidence for an association of rheumatoid arthritis susceptibility with genes involved in B cell differentiation (BACH2) and DNA repair (RAD51B). PMID: 24022229
23. BACH2 competes with BCL6 for promoter binding and reverses BCL6-mediated repression of p53 and other cell cycle checkpoint-control genes. PMID: 23852341
24. Downregulation of BACH2 mediated by Bcr-Abl oncoprotein via PAX5 is associated with chronic myeloid leukaemia. PMID: 22858985
25. crystal structure of the human Bach2 POZ domain is reported at 2.1 A resolution PMID: 22194330
26. This is the first report that shows the involvement of both BCL2L1 and the transcription factor BACH2 in a chromosomal rearrangement. PMID: 21412927
27. BACH2 is transcriptionally regulated by the BCR/ABL oncogene. PMID: 11746976
28. antineoplastic drugs that were oxidative stressors induced the nuclear accumulation of BACH2 PMID: 12829606
29. loss of BACH2 expression through Epstein-Barr virus integration might contribute to lymphomagenesis PMID: 14982850
30. Results demonstrate that transcription activity associated with PML bodies is selectively repressed by the recruitment of Bach2 around PML bodies. PMID: 15060166
31. Upregulation of BACH2 is associated with ovarian cancer PMID: 16832351
32. Bach2 is phosphorylated on S521 via Bcr-Abl signaling thru the phosphatidylinositol-3/S6 kinase pathway,and transcriptionally represses heme oxygenase-1 PMID: 17018862
33. down-regulation of the BACH2 gene through the interaction with centromeric heterochromatin would take part in leukomogenesis of BCR-ABL positive lymphoid leukemia. PMID: 17044046
34. This study demonstrated strong integration clusters in the BACH2 gene were observed in 2 HIV infection patients without detectable viremia. PMID: 17262715
35. expression of the silencing mediator of retinoid and thyroid receptor (SMRT) & histone deacetylase4 (HDAC4) enhances formation of Bach2 foci in nuclear matrix. SMRT mediates HDAC4 binding to Bach2, & HDAC4 facilitates the retention of Bach2 in the foci. PMID: 17383980
36. This study demonstrates a novel role for Bach2 as a key regulator of nucleic acid-triggered antiviral responses in human cells. PMID: 17991429
37. reporter assays demonstrated that Bach2 and Bcl6 cooperate to repress Prdm1 through its intron enhancer region PMID: 18256039
38. BACH2 expression is necessary to maintain IL-2 production when NFAT1 protein is reduced, potentially impacting umbilical cord blood graft CD4(+) T-cell allogeneic responses PMID: 18769450
39. BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation PMID: 18929412

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HGNC: 14078

OMIM: 605394

KEGG: hsa:60468

STRING: 9606.ENSP00000257749

UniGene: Hs.269764