BAG5 Antibody

Code CSB-PA890743HA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: BAG family molecular chaperone regulator 5 antibody at 2μg/ml
    Lane 1: Mouse kidney tissue
    Lane 2: Mouse brain tissue
    Lane 3: Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 52, 57 kDa
    Observed band size: 52 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA890743HA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) BAG5 Polyclonal antibody
Uniprot No. Q9UL15
Target Names BAG5
Alternative Names BAG family molecular chaperone regulator 5 antibody; BAG-5 antibody; BAG5 antibody; BAG5_HUMAN antibody; Bcl 2 associated athanogene 5 antibody; Bcl-2-associated athanogene 5 antibody; BCL2 associated athanogene 5 antibody; KIAA0873 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human BAG family molecular chaperone regulator 5 protein (1-447AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death. De Snoo M L, et al,Cell Death & Disease,2019

Sample type: transfected U2OS GFP-Parkin cells
Sample species: Human
Application: WB
Review: Western blot confirming reduction of endogenous BAG5 protein levels in transfected U2OS GFP-Parkin cells.
PMID: 31787745

Target Data

Function Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
Gene References into Functions
  1. BAG5 was found as a expression variability marker in an 8-cell human embryo. PMID: 26288249
  2. Subsequent BAG5 upregulation ameliorated the tumor-suppressive effects of miR-127-3p overexpression in epithelial ovarian cancer (EOC). In conclusion, miR-127-3p functions as a tumor suppressor in EOC, and its influence on EOC is directly through regulation of BAG5. PMID: 27571744
  3. High BAG5 expression is associated with pancreatic cancer. PMID: 27571739
  4. This study showed that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination. PMID: 25006867
  5. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PMID: 24475098
  6. BAG5 is a binding partners of LRRK2 and part of a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system. PMID: 24510904
  7. Bag5 is overexpressed in prostate cancer and plays a role in endoplamic reticulum-stress induced apoptosis. Furthermore we have identified GRP78/BiP as a novel interaction partner of Bag5. PMID: 23448667
  8. BAG5 directly interacts with Parkin and stabilizes Parkin via the ubiquitin-mediated proteasomal pathway. PMID: 21131737
  9. A novel function for BAG5 as a modulator of CHIP E3 ubiquitin ligase activity with implications for CHIP-mediated regulation of alpha-syn oligomerization. PMID: 21358815
  10. We replicated the association of BCL2L11 and CASP9 with non-Hodgkin's lymphoma risk at the gene and SNP level, and identified novel associations with BCLAF1 and BAG5. PMID: 20855536
  11. Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death. PMID: 15603737

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Database Links

HGNC: 941

OMIM: 603885

KEGG: hsa:9529

STRING: 9606.ENSP00000338814

UniGene: Hs.5443

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