BATF2 Antibody

1. BATF2 gene was modulated after treatment with zebularine and was a poor prognostic marker, since its low levels were correlated with relapse and a poor prognosis for medulloblastoma patients. PMID: 27785591
2. Gain- and loss-of-function studies uncovered a role for Batf2 in myeloid differentiation in both murine and human systems. We thus demonstrate that chronic infection can deplete HSPCs and identify BATF2 as a mediator of infection-induced HSPC terminal differentiation PMID: 27926863
3. Our findings expanded the understanding of the role of BATF2 in tumors, and also suggested a potential of using BATF2 as a therapeutic target to hinder bevacizumab induced epithelial-mesenchymal transition in glioblastoma. PMID: 28739720
4. BATF2 may exert selective pressure on the recombination machinery via a repetitive motif-based mechanism for the maintenance of heterochromatin stability. PMID: 26977016
5. Batf2 has a role in infectious diseases and cancer PMID: 26376615
6. Results demonstrate that SARI is a novel target gene of glucocorticoid receptor, and the upregulation of SARI plays an important role in dexamethasone's killing effect on B lymphoma cells. PMID: 26808579
7. Suggest that SARI might play an important role in the occurrence and development of prostate cancer. IFN-beta might inhibit the growth of prostate cancer and promote cellular apoptosis by inducing the expression of SARI. PMID: 26339361
8. In conclusion, as a tumor suppressor, BATF2 serves as a prognostic biomarker of esophageal squamous cell carcinoma and it may be a potential therapeutic target for ESCC treatment. PMID: 26135942
9. these findings indicate that BATF2 status could be served as a potential biomarker to predict prognosis in colorectal cancer PMID: 26022579
10. these novel findings suggest that BATF2, a tumor suppressor gene, is a potent negative regulator of HGF/MET signaling in colorectal cancer PMID: 25762344
11. BATF2 plays a tumor-suppressor role in the development of oral tongue squamous cell carcinoma and BATF2 may serve as a prognostic biomarker and potential therapeutic target for this disease. PMID: 24252932
12. SARI expression may predict a poor prognosis in non-small cell lung patients, and SARI may serve as a prognostic biomarker and potential therapeutic target for lung cancer. PMID: 24133583
13. MDA-7/IL-24 has a role in cancer-specific apoptosis through SARI induction PMID: 24282278
14. Loss of SARI expression initiates epithelial-to-mesenchymal transition (EMT), which is visualized by repression of E-cadherin and up-regulation of vimentin in lung adenocarcinoma cell lines and in clinical lung adenocarcinoma specimens. PMID: 23049725
15. BCR-ABL mediates the down-regulation of SARI mRNA expression in K562 cells. PMID: 21867603
16. Data suggest that SARI as a potential therapeutic target in CML. PMID: 21892628
17. Decreased expression of BATF2 is associated with hepatocellular carcinoma. PMID: 20473897
18. Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1. PMID: 20531301

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HGNC: 25163

OMIM: 614983

KEGG: hsa:116071

STRING: 9606.ENSP00000301887

UniGene: Hs.124840