BCL7A Antibody

Code CSB-PA040224
Size US$100
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Product Details

Uniprot No.
Target Names
BCL7A
Alternative Names
B cell CLL/lymphoma 7 antibody; B cell CLL/lymphoma 7 protein family member A antibody; B cell CLL/lymphoma 7A antibody; B-cell CLL/lymphoma 7 protein family member A antibody; BCL 7 antibody; BCL7 antibody; bcl7a antibody; BCL7A_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human Bcl-7a.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. BCL7A, BRWD3, and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations. PMID: 29166413
  2. Data suggest that BCL7A may play an important role in cutaneous T-cell lymphoma (CTCL) carcinogenesis. PMID: 22856870
  3. Report describes BCL7A protein expression in normal lymphoid tissues and lymphomas using immunohistochemistry. PMID: 23043359
  4. Promoter hypermethylation of BCL7a is associated with cutaneous T-cell lymphoma PMID: 15897551
  5. deletion of genes BCL7A in early-stage mycosis fungoides. PMID: 18663754
  6. Variants in BCL7A were strongly related to diffuse large B-cell lymphoma. PMID: 19336552

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Involvement in disease
Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.
Protein Families
BCL7 family
Database Links

HGNC: 1004

OMIM: 601406

KEGG: hsa:605

UniGene: Hs.530970

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