BLMH Antibody

Code CSB-PA002716ESR1HU
Size US$166
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) BLMH Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
BH antibody; Bleomycin hydrolase antibody; BLM hydrolase antibody; BLMH antibody; BLMH_HUMAN antibody; BMH antibody; EC antibody
Raised in
Species Reactivity
Recombinant Human Bleomycin hydrolase protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Gene References into Functions
  1. the BLMH gene single nucleotide polymorphism A1450G (rs1050565) influences BLMH activity and late pulmonary toxicity. PMID: 27327270
  2. Ubc9 plays different roles of action in antitumor agents in chemotherapy. The process requires bleomycin hydrolase and poly(ADP-ribose) polymerase-1. The results are beneficial to deeply understanding of Ubc9 functions and for precise prediction of chemotherapy outcomes in tumors. PMID: 27878232
  3. Bleomycin hydrolase downregulation in lesional skin of adult atopic dermatitis patients is independent of filaggrin gene mutations PMID: 25240784
  4. This study findings suggest that Blmh interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis. PMID: 24496069
  5. We also detected significant association between XRCC1, XRCC3, and BLHX polymorphisms and a high frequency of chromosomal damage PMID: 24615029
  6. The caspase-dependent cleavage of BLH was confirmed by cleavage of partly-purified human bleomycin hydrolase with caspase-3. PMID: 23708668
  7. BH may play an important role during the late stage of epidermal differentiation. PMID: 22037625
  8. present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC PMID: 21943823
  9. This first report on BLMH carrier status in Tunisia shows o association between carrying the BLMH-G genotype and Alzheimer's disease in epsilon4 negative or positive subjects. PMID: 20198498
  10. Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin. PMID: 21310951
  11. BH activity and expression were markedly decreased in AD lesional skin, suggesting a defect of the filaggrin degradation pathway in AD. PMID: 21190945
  12. Polymorphism is associated with neurodegenerative diseases, notably Alzheimer disease. PMID: 12604387
  13. Significant effect of BLHX variant alleles (A/G, G/G) on the chromosome damage induced by bleomycin. PMID: 18082847
  14. The homozygous variant G/G of BLMH gene SNP A1450G is associated with reduced survival and higher prevalence of early relapses in TC patients treated with bleomycin-containing chemotherapy. PMID: 18398146

Show More

Hide All

Subcellular Location
Cytoplasm. Cytoplasmic granule.
Protein Families
Peptidase C1 family
Database Links

HGNC: 1059

OMIM: 602403

KEGG: hsa:642

STRING: 9606.ENSP00000261714

UniGene: Hs.371914

Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
Join Us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2023 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1