BLOC1S2 Antibody

Datasheet

Code	CSB-PA754307ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA754307ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA754307ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BLOC1S2 Polyclonal antibody

Uniprot No.

Q6QNY1

Target Names

BLOC1S2

Alternative Names

Biogenesis of lysosome-related organelles complex 1 subunit 2 antibody; BL1S2_HUMAN antibody; BLOC-1 subunit 2 antibody; Bloc1s2 antibody; BLOS2 antibody; Centrosome-associated protein antibody; RP11 316M21.4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 2 protein (44-142AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.

Gene References into Functions

WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells PMID: 20308062
BLOC1S2 protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. Over-expression of BLOC1S2 in the presence or absence of HIPPI does not induce apoptosis. PMID: 18188704
we have explored ways of efficiently gathering high-quality information about candidate binding partners fob bloc1s2 PMID: 19083121
Biogenesis of lysosome-related organelles complex-1 (BLOC-1) subunit 2 (BLOS2).BLOC-1 is required for the biogenesis of melanosomes and platelet dense granules. PMID: 15102850

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane.

Protein Families

BLOC1S2 family

Tissue Specificity

Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level).

Database Links

HGNC: 20984

OMIM: 609768

KEGG: hsa:282991

STRING: 9606.ENSP00000359398

UniGene: Hs.34906

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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