BLVRB Antibody, HRP conjugated

Datasheet

Code	CSB-PA002722HB01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BLVRB Polyclonal antibody

Uniprot No.

P30043

Target Names

BLVRB

Alternative Names

Biliverdin IX beta reductase antibody; biliverdin reductase B (flavin reductase (NADPH)) antibody; Biliverdin reductase B antibody; Biliverdin-IX beta-reductase antibody; BLVRB antibody; BLVRB_HUMAN antibody; BVR B antibody; BVR-B antibody; BVRB antibody; epididymis secretory protein Li 10 antibody; Flavin reductase (NADPH) antibody; Flavin reductase antibody; FLR antibody; FR antibody; GHBP antibody; Green heme binding protein antibody; Green heme-binding protein antibody; HEL-S-10 antibody; Methemoglobin reductase antibody; MGC117413 antibody; NADPH dependent diaphorase antibody; NADPH flavin reductase antibody; NADPH-dependent diaphorase antibody; NADPH-flavin reductase antibody; SDR43U1 antibody; short chain dehydrogenase/reductase family 43U; member 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Flavin reductase (NADPH) protein (2-206AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.

Gene References into Functions

These results provide promising chemical scaffolds for the development of enhanced BLVRB inhibitors and identify chemical probes to better dissect the role of biliverdins, alternative substrates, and BLVRB function in physiologically relevant cellular contexts. PMID: 29487133
These data define the first physiologically relevant function of BLVRB and implicate its activity and/or heme-regulated BV tetrapyrrole(s) in a unique redox-regulated bioenergetic pathway. PMID: 27207795
miR-127-5p suppressed NF-kappaB activity by directly targeting BLVRB in hepatocellular carcinoma cells. PMID: 26708147
quantum mechanics/molecular mechanics potential energy surfaces show that the lowest energy pathway proceeds with a positively charged pyrrole intermediate via two transition states PMID: 18241201

Subcellular Location

Cytoplasm.

Tissue Specificity

Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum.

Database Links

HGNC: 1063

OMIM: 600941

KEGG: hsa:645

STRING: 9606.ENSP00000263368

UniGene: Hs.515785

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Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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