BOLA3 Antibody

Code CSB-PA690486LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA690486LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) BOLA3 Polyclonal antibody
Uniprot No.
Target Names
BOLA3
Alternative Names
BolA-like protein 3 antibody; BOLA3 antibody; BOLA3_HUMAN antibody; MMDS2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human BolA-like protein 3 protein (1-79AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The BOLA3 Antibody (Product code: CSB-PA690486LA01HU) is Non-conjugated. For BOLA3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA690486LB01HU BOLA3 Antibody, HRP conjugated ELISA
FITC CSB-PA690486LC01HU BOLA3 Antibody, FITC conjugated
Biotin CSB-PA690486LD01HU BOLA3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1.
Gene References into Functions
  1. Clinical features of BOLA3-associated variant nonketotic hyperglycemia include severe neurodegeneration after a period of normal development. PMID: 24334290
  2. BOLA3 plays a crucial role in the biogenesis of iron-sulfur clusters. PMID: 22562699
  3. Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes [case report] PMID: 21944046
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  5. This study reported that all three human BolA proteins (hBolA1, hBolA2, and hBolA3) are novel non-classical secreted proteins identified with bioinformatics and molecular biology experiments. PMID: 18548201
  6. BOLA-like proteins are widely conserved from prokaryotes to eukaryotes and may be involved in cell proliferation or cell-cycle regulation. PMID: 14718656

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Involvement in disease
Multiple mitochondrial dysfunctions syndrome 2 with hyperglycinemia (MMDS2)
Subcellular Location
Mitochondrion.
Protein Families
BolA/IbaG family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 24415

OMIM: 613183

KEGG: hsa:388962

STRING: 9606.ENSP00000331369

UniGene: Hs.61472

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