BRINP1 Antibody

1. Results found that the expression of DBCCR1 is significantly lower in the lung cancer tissues compared with adjacent non-tumor tissues of patients, and correlates with more advanced stages of cancer, and shorter survival of patients. Interestingly, DBCCR1 attenuates the expression of DNMT1, suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation. PMID: 28427182
2. we found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter PMID: 23349863
3. DBC1 modulates the stability and function of the nuclear receptor Rev-erb-alpha. PMID: 23398316
4. the stress-induced DBC1-SIRT1 interaction is important for cell fate determination following genotoxic stress. PMID: 22465953
5. Rxpression of DBC1 and SIRT1 is a significant prognostic indicator for breast carcinoma patients. PMID: 21056897
6. High DBC1 expression is associated with breast and lung cancer.. PMID: 20429629
7. DBCCR1 is involved in the process of bladder tumorigenesis PMID: 12442002
8. the prevalent inactivation of DBCCR1 seen at the expression level in astrocytomas is not primarily caused by genomic loss of the gene. PMID: 15643521
9. likely tumor suppressor for NSCLC;silencing through homozygous deletion or methylation of its promoter promotes progression PMID: 15746151
10. hypermethylation of the DBC1 promoter region is a frequent event during the development of lymphoproliferative malignancies PMID: 18264085

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HGNC: 2687

OMIM: 602865

KEGG: hsa:1620

STRING: 9606.ENSP00000265922

UniGene: Hs.532316