BMP/retinoic acid-inducible neural-specific protein 1 antibody; BRINP1 antibody; DBC1 antibody; DBC1_HUMAN antibody; DBCCR1 antibody; Deleted in bladder cancer protein 1 antibody; Deleted in bladder cancer protein 1 precursor antibody; FAM5A antibody; IB3089A antibody; Protein FAM5A antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DBC1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.
Gene References into Functions
Results found that the expression of DBCCR1 is significantly lower in the lung cancer tissues compared with adjacent non-tumor tissues of patients, and correlates with more advanced stages of cancer, and shorter survival of patients. Interestingly, DBCCR1 attenuates the expression of DNMT1, suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation. PMID: 28427182
we found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter PMID: 23349863
DBC1 modulates the stability and function of the nuclear receptor Rev-erb-alpha. PMID: 23398316
the stress-induced DBC1-SIRT1 interaction is important for cell fate determination following genotoxic stress. PMID: 22465953
Rxpression of DBC1 and SIRT1 is a significant prognostic indicator for breast carcinoma patients. PMID: 21056897
High DBC1 expression is associated with breast and lung cancer.. PMID: 20429629
DBCCR1 is involved in the process of bladder tumorigenesis PMID: 12442002
the prevalent inactivation of DBCCR1 seen at the expression level in astrocytomas is not primarily caused by genomic loss of the gene. PMID: 15643521
likely tumor suppressor for NSCLC;silencing through homozygous deletion or methylation of its promoter promotes progression PMID: 15746151
hypermethylation of the DBC1 promoter region is a frequent event during the development of lymphoproliferative malignancies PMID: 18264085
Show More
Hide All
Subcellular Location
Cytoplasm.
Protein Families
BRINP family
Tissue Specificity
Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.