C1D Antibody

Datasheet

Code	CSB-PA03474A0Rb
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate All lanes: C1D antibody at 3.2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 17 kDa Observed band size: 17 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA03474A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA03474A0Rb at dilution of 1:100 Immunofluorescence staining of Hela cells with CSB-PA03474A0Rb at 1:533, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) C1D Polyclonal antibody

Uniprot No.

Q13901

Target Names

C1D

Alternative Names

1110036E10Rik antibody; AI875855 antibody; C1D antibody; C1D DNA binding protein antibody; C1D_HUMAN antibody; hC1D antibody; LRP1 antibody; MGC12261 antibody; MGC14659 antibody; MGC188504 antibody; Nuclear DNA binding protein antibody; Nuclear nucleic acid binding protein C1D antibody; Nuclear nucleic acid-binding protein C1D antibody; rCG23324 antibody; RGD1560600 antibody; Small unique nuclear receptor corepressor antibody; SUNCOR antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Nuclear nucleic acid-binding protein C1D protein (1-135AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The C1D Antibody (Product code: CSB-PA03474A0Rb) is Non-conjugated. For C1D Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA03474B0Rb	C1D Antibody, HRP conjugated	ELISA
FITC	CSB-PA03474C0Rb	C1D Antibody, FITC conjugated
Biotin	CSB-PA03474D0Rb	C1D Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:2000-1:10000
IHC	1:50-1:500
IF	1:500-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB.

Gene References into Functions

C1D is associated with the DNA repair complex and may promote repair of ultraviolet irradiation-induced DNA damage. PMID: 20530579
Results are consistent with a role for the exosome-associated protein C1D in the recruitment of the exosome to pre-rRNA to mediate the 3' end processing of the 5.8S rRNA. PMID: 17412707
Anti-C1D autoantibodies were observed in patients with polymyositis-scleroderma overlap syndrome. PMID: 17599775
TRAX enhances the DNA binding capacity of Translin, that binds to recombination regions in some malignancies. C1D interacts with TRAX following g-irradiation and prevents formation of TRAX/Translin complex, thereby inhibits any unwanted recombination. PMID: 11801738
The C1D protein interacts with the catalytic subunit of DNA-PK and is a very effective substrate for DNA-PK in vitro. Moreover, C1D directs the activation of DNA-PK in a manner that does not require DNA termini, suggesting a role for C1D in DNA repair. PMID: 9679063

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Subcellular Location

Nucleus. Cytoplasm. Nucleus, nucleolus.

Protein Families

C1D family

Tissue Specificity

Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung an

Database Links

HGNC: 29911

OMIM: 606997

KEGG: hsa:10438

STRING: 9606.ENSP00000348107

UniGene: Hs.602900

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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