C8G Antibody

Code CSB-PA004196LA01HU
Size US$166
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  • Western blot
    All lanes: C8G antibody at 2µg/ml + Human serum
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 23 kDa
    Observed band size: 23 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) C8G Polyclonal antibody
Uniprot No.
Target Names
C8G
Alternative Names
C8C antibody; C8G antibody; CO8G_HUMAN antibody; Complement component 8 gamma polypeptide antibody; Complement component C8 gamma chain antibody; MGC142186 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Complement component C8 gamma chain protein (21-202AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The C8G Antibody (Product code: CSB-PA004196LA01HU) is Non-conjugated. For C8G Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004196LB01HU C8G Antibody, HRP conjugated ELISA
FITC CSB-PA004196LC01HU C8G Antibody, FITC conjugated
Biotin CSB-PA004196LD01HU C8G Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
Gene References into Functions
  1. Binding of C8 gamma subunit to C8 beta is dependent on the thrombospondin type 1 module + low-density lipoprotein receptor class A module + membrane attack complex/perforin domain of C8 beta. PMID: 12220191
  2. structure of a C8gamma.laurate complex revealed Y83 and Y131 can move to allow penetration of hydrocarbon chain of laurate into the lower cavity. A Y83W mutation blocked access but had no effect on the ability of C8gamma to enhance C8 cytolytic activity PMID: 17452033
Subcellular Location
Secreted.
Protein Families
Calycin superfamily, Lipocalin family
Database Links

HGNC: 1354

OMIM: 120930

KEGG: hsa:733

STRING: 9606.ENSP00000224181

UniGene: Hs.1285

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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