C8G Antibody

Datasheet

Code	CSB-PA004196LA01HU
Size	US$166
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Image	Western blot All lanes: C8G antibody at 2µg/ml + Human serum Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 23 kDa Observed band size: 23 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) C8G Polyclonal antibody

Uniprot No.

P07360

Target Names

C8G

Alternative Names

C8C antibody; C8G antibody; CO8G_HUMAN antibody; Complement component 8 gamma polypeptide antibody; Complement component C8 gamma chain antibody; MGC142186 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Complement component C8 gamma chain protein (21-202AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The C8G Antibody (Product code: CSB-PA004196LA01HU) is Non-conjugated. For C8G Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004196LB01HU	C8G Antibody, HRP conjugated	ELISA
FITC	CSB-PA004196LC01HU	C8G Antibody, FITC conjugated
Biotin	CSB-PA004196LD01HU	C8G Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

Gene References into Functions

Binding of C8 gamma subunit to C8 beta is dependent on the thrombospondin type 1 module + low-density lipoprotein receptor class A module + membrane attack complex/perforin domain of C8 beta. PMID: 12220191
structure of a C8gamma.laurate complex revealed Y83 and Y131 can move to allow penetration of hydrocarbon chain of laurate into the lower cavity. A Y83W mutation blocked access but had no effect on the ability of C8gamma to enhance C8 cytolytic activity PMID: 17452033

Subcellular Location

Secreted.

Protein Families

Calycin superfamily, Lipocalin family

Database Links

HGNC: 1354

OMIM: 120930

KEGG: hsa:733

STRING: 9606.ENSP00000224181

UniGene: Hs.1285

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Complement and coagulation cascades

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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