CACNA2D4 Antibody

Datasheet

Code	CSB-PA801802LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA801802LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA801802LA01HU at dilution of 1:100 Immunofluorescence staining of HepG2 cells with CSB-PA801802LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CACNA2D4 Polyclonal antibody

Uniprot No.

Q7Z3S7

Target Names

CACNA2D4

Alternative Names

CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4 antibody; Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-4 protein (934-1115AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CACNA2D4 Antibody (Product code: CSB-PA801802LA01HU) is Non-conjugated. For CACNA2D4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA801802LB01HU	CACNA2D4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA801802LC01HU	CACNA2D4 Antibody, FITC conjugated
Biotin	CSB-PA801802LD01HU	CACNA2D4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.

Gene References into Functions

We have confirmed the TRPM1 36,445 bp deletion is a founder mutation in the Ashkenazi-Jewish (AJ) population with a carrier rate of 1 in 50. We have also confirmed the 35,741 bp deletion in the CACNA2D4 gene is a founder mutation in the AJ population with a carrier rate of 1 in 56. PMID: 28726569
This report describes a distinctive ERG phenotype, predominantly involving the cone pathways, in 2 unrelated patients from different ethnic backgrounds with homozygous mutations in CACNA2D4 and normal retinal imaging PMID: 26560832
A rare, partial deletion of 35.7 kb in CACNA2D4 in two unrelated late onset bipolar I patients and in one control individual, were identified. PMID: 22488967
Calcium channel alpha(2)delta-4 subunit has limited distribution in special cell types of the pituitary, adrenal gland, colon, and fetal liver. PMID: 12181424

Involvement in disease

Retinal cone dystrophy 4 (RCD4)

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Calcium channel subunit alpha-2/delta family

Tissue Specificity

Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophils of the pi

Database Links

HGNC: 20202

OMIM: 608171

KEGG: hsa:93589

STRING: 9606.ENSP00000372169

UniGene: Hs.13768

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

MAPK signaling pathway Cardiac muscle contraction

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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