CACNG8 Antibody

Code CSB-PA823907OA01HU
Size US$166
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Image
  • IHC image of CSB-PA823907OA01HU diluted at 1:700 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CACNG8 Polyclonal antibody
Uniprot No.
Target Names
CACNG8
Alternative Names
CACNG8; CACNG6; Voltage-dependent calcium channel gamma-8 subunit; Neuronal voltage-gated calcium channel gamma-8 subunit; Transmembrane AMPAR regulatory protein gamma-8; TARP gamma-8
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence from Human Voltage-dependent calcium channel gamma-8 subunit protein (65-83AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CACNG8 Antibody (Product code: CSB-PA823907OA01HU) is Non-conjugated. For CACNG8 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA823907OB01HU CACNG8 Antibody, HRP conjugated ELISA
FITC CSB-PA823907OC01HU CACNG8 Antibody, FITC conjugated
Biotin CSB-PA823907OD01HU CACNG8 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:500-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.
Gene References into Functions
  1. These results indicate that CACNG4, CACNG5, CACNG6 and CACNG8 may contribute to the risk of SCZ. The statistical epistasis identified between CACNG5 and CACNG6 suggests that there may be an underlying biological interaction between the two genes. PMID: 27102562
  2. Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction PMID: 26710323
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane.
Protein Families
PMP-22/EMP/MP20 family, CACNG subfamily
Tissue Specificity
Detected in heart left ventricle.
Database Links

HGNC: 13628

OMIM: 606900

KEGG: hsa:59283

STRING: 9606.ENSP00000270458

UniGene: Hs.631595

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