CAPN5 Antibody

1. The relative domain rotation of 60-100 degrees we found for mini-calpain-5 (a non-classical calpain) is significantly greater than the largest rotation previously observed for a classical calpain PMID: 27474374
2. CAPN5 localization at the photoreceptor synapse and with mitochondria explains the neural circuitry phenotype in human CAPN5 disease alleles. PMID: 27152965
3. A novel CAPN5 (c.750G>T, p.Lys250Asn) missense mutation causes uveitis and neovascular retinal detachment. PMID: 25856303
4. CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation PMID: 25994508
5. CAPN5 expression can be suppressed by shRNA-based RNA interference PMID: 25216694
6. autosomal dominant neovascular inflammatory vitreoretinopathy is due to CAPN5 gain-of-function rather than haploinsufficiency. PMID: 24381307
7. Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration. PMID: 23055945
8. Results describe the cloning and characterization of rat calpain-5, which is highly homologous to human and mouse sequences. PMID: 15464980
9. CAPN5 polymorphisms are associated with a risk of polycystic ovary syndrome. PMID: 16396936
10. CAPN5 seems to influence traits related to increased risk for cardiovascular diseases and play a role as a candidate gene for metabolic syndrome PMID: 17227582
11. We have found significant interaction between CAPN5 and PPARD genes that reduces risk for obesity in 55%. CAPN5 and PPARD gene products may also interact in vivo. PMID: 18657264
12. Data examine possible allelic imbalance in papillary thyroid cancer at EMSY, CAPN5, and PAK1, as candidate genes within 11q13.5-q14 region using a single nucleotide polymorphism-based analysis. PMID: 18787380
13. Calpain5 was expressed in endometrial stromal and glandular cells throughout the menstrual cycle and in decidua, and its expression was decreased in both stromal and glandular cells from women with endometriosis compared with that of fertile controls. PMID: 18829447

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HGNC: 1482

OMIM: 193235

KEGG: hsa:726

STRING: 9606.ENSP00000278559

UniGene: Hs.248153