CARD16 Antibody

Code CSB-PA682727LA01HU
Size US$166
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  • Immunofluorescence staining of Hela cells with CSB-PA682727LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CARD16 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
CAR16_HUMAN antibody; CARD only domain-containing protein 1 antibody; CARD only protein antibody; CARD16 antibody; Caspase recruitment domain family, member 16 antibody; Caspase recruitment domain-containing protein 16 antibody; Caspase-1 dominant-negative inhibitor pseudo-ICE antibody; Caspase-1 inhibitor COP antibody; COP antibody; COP1 antibody; Pseudo interleukin 1 beta converting enzyme antibody; Pseudo interleukin-1 beta converting enzyme antibody; Pseudo interleukin-1beta converting enzyme antibody; PSEUDO-ICE antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Caspase recruitment domain-containing protein 16 protein (1-197AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CARD16 Antibody (Product code: CSB-PA682727LA01HU) is Non-conjugated. For CARD16 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA682727LB01HU CARD16 Antibody, HRP conjugated ELISA
FITC CSB-PA682727LC01HU CARD16 Antibody, FITC conjugated
Biotin CSB-PA682727LD01HU CARD16 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
Gene References into Functions
  1. Expression of NOX4/p22(phox) as well as ROS production is enhanced by IL-1beta. On the other hand, the use of NOX4 inhibitors decreased IL-1beta-induced collagenase synthesis by chondrocytes. PMID: 26521743
  2. Caspase-1-mediated cell death is regulated, at least in part, by the balance of Rip2 and Cop; alterations of this balance may contribute to aberrant caspase-1-mediated pathogenesis in Huntington's disease. PMID: 16354923
  3. Cop inhibition of cell death, at least to a certain extent, results from its interference with the activation of caspase-1 and caspase-4. PMID: 16920334
Tissue Specificity
Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
Database Links

HGNC: 33701

OMIM: 615680

KEGG: hsa:114769

STRING: 9606.ENSP00000364858

UniGene: Hs.348365

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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