CASTOR2 Antibody, Biotin conjugated

Code CSB-PA28239D0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CASTOR2 Polyclonal antibody
Uniprot No.
Target Names
CASTOR2
Alternative Names
CASTOR2 antibody; Cellular arginine sensor for mTORC1 protein 2 antibody; GATL2_HUMAN antibody; GATS-like protein 2 antibody; GATSL2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Gene References into Functions
  1. Study establishes the CASTOR1 homodimer and CASTOR1-CASTOR2 heterodimer as arginine sensors for the mTORC1 pathway. PMID: 26972053
Subcellular Location
Cytoplasm, cytosol.
Protein Families
GATS family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 37073

OMIM: 617033

KEGG: hsa:729438

UniGene: Hs.594823

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