CASTOR2 Antibody

Datasheet
Code CSB-PA28239A0Rb
See More Details Free Antibody trial simple
Size US$299
Image
  • Western Blot
    Positive WB detected in: HL60 whole cell lysate, SH-SY5Y whole cell lysate, Jurkat whole cell lysate, Hela whole cell lysate
    All lanes: CASTOR2 antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 37 kDa
    Observed band size: 37 kDa

Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CASTOR2 Polyclonal antibody
Uniprot No. A6NHX0
Target Names CASTOR2
Alternative Names Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2), CASTOR2, GATSL1 GATSL2
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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Target Data

Function Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Subcellular Location Cytoplasm, cytosol
Protein Families GATS family
Tissue Specificity Widely expressed.
Database Links

HGNC: 37073

OMIM: 617033

KEGG: hsa:729438

UniGene: Hs.594823

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