CASTOR2 Antibody

Datasheet

Code	CSB-PA28239A0Rb
Size	US$166
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Image	Western Blot Positive WB detected in: HL60 whole cell lysate, SH-SY5Y whole cell lysate, Jurkat whole cell lysate, Hela whole cell lysate All lanes: CASTOR2 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 37 kDa Observed band size: 37 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CASTOR2 Polyclonal antibody

Uniprot No.

A6NHX0

Target Names

CASTOR2

Alternative Names

CASTOR2 antibody; Cellular arginine sensor for mTORC1 protein 2 antibody; GATL2_HUMAN antibody; GATS-like protein 2 antibody; GATSL2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CASTOR2 Antibody (Product code: CSB-PA28239A0Rb) is Non-conjugated. For CASTOR2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA28239B0Rb	CASTOR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA28239C0Rb	CASTOR2 Antibody, FITC conjugated
Biotin	CSB-PA28239D0Rb	CASTOR2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

Gene References into Functions

Study establishes the CASTOR1 homodimer and CASTOR1-CASTOR2 heterodimer as arginine sensors for the mTORC1 pathway. PMID: 26972053

Subcellular Location

Cytoplasm, cytosol.

Protein Families

GATS family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 37073

OMIM: 617033

KEGG: hsa:729438

UniGene: Hs.594823

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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